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Nucleobindin 2 (NUCB2) is a calcium-binding protein with predominant expression in the pituitary gland in both human and mouse, although it is additionally seen across many other human organs too. In the mouse brain, moderate-intensity cytoplasmic somatic neuronal immunostaining is noticed in the lateral septum, caudate putamen, hippocampus CA2, piriform cortex, throughout the entire neocortex and amygdala nuclei. Strong intensity cytoplasmic somatic neuronal immunostaining is noticed in the hypothalamic paraventricular nucleus, supraoptic nucelus, arcuate nucleus, in the locus coeruleus, thalamic parafascicular nucleus, dorsal raphe and in the laterodorsal tegmental nucleus. Area postrema cells are also immunoreactive.
Positive cells and structuresi
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.
Soma in neurons. Circumventricular organs of ependymal cells.
Strong-intensity neuronal somatic immunostaining in the paraventicular nucleus