[{"Gene":"SERPINE2","Gene synonym":["GDN","nexin","PI7","PN1","PNI"],"Ensembl":"ENSG00000135919","Gene description":"Serpin family E member 2","Uniprot":["P07093"],"Chromosome":"2","Position":"223975045-224039318","Protein class":["Plasma proteins","Predicted secreted proteins"],"Biological process":["Differentiation","Neurogenesis"],"Molecular function":["Developmental protein","Heparin-binding","Protease inhibitor","Serine protease inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"ovary":"284.1","placenta":"1054.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Astrocytes":"221.1","Extravillous trophoblasts":"605.0","Granulosa cells":"395.3","Leydig cells":"405.7","Melanocytes":"216.4","Ovarian stromal cells":"442.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"astrocyte":"364.2","bergmann glia":"536.0","oligodendrocyte precursor cell":"322.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in all","RNA cancer specificity score":"4","RNA cancer specific FPKM":{"Skin Cuteneous Melanoma (TCGA)":"1368.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"12","RNA blood cell specific nTPM":{"naive CD4 T-cell":"13.0","naive CD8 T-cell":"6.9","NK-cell":"23.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"NK-cells":"23.3","T-cells":"13.0"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in all","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"skin cancer":"2214.3"},"RNA tissue cell type enrichment":["Liver - Hepatic stellate cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA000277"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus"],"Secretome location":"Secreted in female reproductive system","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"11000000","Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 58: Placenta - Pregnancy","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 50: Connective tissue cells - ECM organization","Interactions":2,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA000277":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.86e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.37e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.75e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.53e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.78e-4"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.51e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.21e-2"}}]