[{"Gene":"HAL","Gene synonym":["HIS"],"Ensembl":"ENSG00000084110","Gene description":"Histidine ammonia-lyase","Uniprot":["P42357"],"Chromosome":"12","Position":"95972662-95996365","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Histidine metabolism"],"Molecular function":["Lyase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"liver":"193.3","skin 1":"59.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Glandular and luminal cells":"15.9","Hepatocytes":"97.9","Kupffer cells":"14.6","monocytes":"28.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"endothelial cell":"1.6","leukocyte":"2.7"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"10","RNA cancer specific FPKM":{"Liver Hepatocellular Carcinoma (TCGA)":"34.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"57.0","neutrophil":"73.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"73.6"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Leukemia":"6.6","liver cancer":"3.0"},"RNA tissue cell type enrichment":["Adipose visceral - Neutrophils","Heart muscle - Neutrophils","Lung - Neutrophil_2","Pituitary gland - Somatotropes","Skeletal muscle - Neutrophils","Skin - Keratinocyte (granular)","Spleen - Neutrophils","Stomach - Neutrophils"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA038547","HPA038548"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"220000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 83: Liver - Metabolism","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 62: Hepatocytes - Metabolism","Interactions":34,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA038547":"AB_10669541","HPA038548":"AB_10673175"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.19e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KRTAP5-6","Gene synonym":["KRTAP5.6"],"Ensembl":"ENSG00000205864","Gene description":"Keratin associated protein 5-6","Uniprot":["Q6L8G9"],"Chromosome":"11","Position":"1697195-1697755","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"liver":"2.9","skin 1":"1.1"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Hair cortex cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 83: Liver - Metabolism","Brain expression cluster":null,"Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":null,"Interactions":81,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"WNT3","Gene synonym":["INT4","MGC131950","MGC138321","MGC138323"],"Ensembl":"ENSG00000108379","Gene description":"Wnt family member 3","Uniprot":["P56703"],"Chromosome":"17","Position":"46762506-46833154","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":["Developmental protein"],"Disease involvement":["Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"liver":"12.0","skin 1":"26.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Basal keratinocytes":"26.2","Early spermatids":"12.3","Late spermatids":"68.9","Suprabasal keratinocytes":"13.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"bergmann glia":"57.0","thalamic excitatory":"44.7"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific FPKM":{"Testicular Germ Cell Tumor (TCGA)":"13.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Keratinocyte (other)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA049893"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":"Secreted to extracellular matrix","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 13: Skin - Cornification","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 11: Late spermatids - Unknown function","Interactions":2,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA049893":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.09e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.48e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null}]