[{"Gene":"SLC6A4","Gene synonym":["5-HTT","HTT","OCD1","SERT1"],"Ensembl":"ENSG00000108576","Gene description":"Solute carrier family 6 member 4","Uniprot":["P31645"],"Chromosome":"17","Position":"30194319-30236002","Protein class":["FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Neurotransmitter transport","Transport"],"Molecular function":null,"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"intestine":"39.2","lung":"27.9","placenta":"17.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"10","RNA single cell type specific nTPM":{"Cytotrophoblasts":"119.5","Proximal enterocytes":"100.4","Syncytiotrophoblasts":"95.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"splatter":"6.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific FPKM":{"Breast Invasive Carcinoma (TCGA)":"3.8"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"11","RNA brain regional specific nTPM":{"midbrain":"507.8","pons":"183.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"colorectal cancer":"2.5","liver cancer":"1.4"},"RNA tissue cell type enrichment":["Pancreas - Alpha cells"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"midbrain":"58.4"},"RNA pig brain regional specificity":"Group enriched","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":"8","RNA pig brain regional specific nTPM":{"midbrain":"51.2","pons":"38.2"},"Antibody":["HPA054723","HPA071354","HPA074728"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Supported","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Small intestine - Absorption","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 24: Cytotrophoblasts - Mitochondria","Interactions":8,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA054723":null,"HPA071354":null,"HPA074728":"AB_2686708"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.90e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null}]