[{"Gene":"AASS","Gene synonym":["LKRSDH","LORSDH"],"Ensembl":"ENSG00000008311","Gene description":"Aminoadipate-semialdehyde synthase","Uniprot":["Q9UDR5"],"Chromosome":"7","Position":"122064583-122144308","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Multifunctional enzyme","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"43.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Astrocytes":"138.4","Hepatocytes":"220.5","Oligodendrocytes":"123.3","Ovarian stromal cells":"129.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"bergmann glia":"263.2","committed oligodendrocyte precursor":"267.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"34.8"},"RNA tissue cell type enrichment":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA020637","HPA020728","HPA020734"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"20000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 53: Non-specific - Glycosylation","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 6: Ovarian stromal cells - Transcription","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA020637":"AB_1844415","HPA020728":"AB_1844416","HPA020734":"AB_1844417"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.30e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.65e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.36e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.54e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.76e-2"}},{"Gene":"ACADM","Gene synonym":["ACAD1","MCAD","MCADH"],"Ensembl":"ENSG00000117054","Gene description":"Acyl-CoA dehydrogenase medium chain","Uniprot":["P11310"],"Chromosome":"1","Position":"75724431-75787575","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"356.4","skeletal muscle":"367.9","tongue":"458.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nTPM":{"Cardiomyocytes":"632.8","Distal tubular cells":"233.6","Hepatocytes":"279.0","Proximal tubular cells":"524.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Skeletal muscle - Skeletal myocytes","Skin - Sebaceous gland cells","Testis - Spermatogonia","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA006198","HPA026542"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Calyx","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"560000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 35: Non-specific - Mitochondria","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 56: Proximal tubular cells - Amino acid metabolism","Interactions":12,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Calyx","Principal piece"],"Antibody RRID":{"HPA006198":"AB_1078087","HPA026542":"AB_1844469"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.92e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.30e-13"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.48e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.10e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.56e-2"}},{"Gene":"ACADS","Gene synonym":["ACAD3","SCAD"],"Ensembl":"ENSG00000122971","Gene description":"Acyl-CoA dehydrogenase short chain","Uniprot":["P16219"],"Chromosome":"12","Position":"120725774-120740008","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"239.5","skeletal muscle":"152.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Distal enterocytes":"338.4","Hepatocytes":"197.4","Proximal enterocytes":"428.7","Undifferentiated cells":"136.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":{"Kidney Chromophobe (TCGA)":"113.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA004799","CAB019284","HPA022271"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Mitochondria","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9100","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 83: Liver - Metabolism","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 5: Enterocytes - Absorption","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Centrosome","Mid piece","Principal piece","End piece"],"Antibody RRID":{"CAB019284":null,"HPA004799":"AB_1844471","HPA022271":"AB_1844472"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.09e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.69e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.34e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.61e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.06e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.40e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.51e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.09e-4"}},{"Gene":"ACADSB","Gene synonym":["ACAD7","SBCAD"],"Ensembl":"ENSG00000196177","Gene description":"Acyl-CoA dehydrogenase short\/branched chain","Uniprot":["P45954"],"Chromosome":"10","Position":"123008979-123058290","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"liver":"349.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nTPM":{"Hepatocytes":"468.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"44.3"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Skeletal muscle - Skeletal myocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA041458","HPA063555"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"20000","Blood expression cluster":"Cluster 39: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 1: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 43: Hepatocytes - Metabolism","Interactions":6,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA041458":"AB_2677491","HPA063555":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.60e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.83e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.76e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.40e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.72e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.63e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.76e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.99e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.03e-1"}},{"Gene":"ACADVL","Gene synonym":["ACAD6","LCACD","VLCAD"],"Ensembl":"ENSG00000072778","Gene description":"Acyl-CoA dehydrogenase very long chain","Uniprot":["P49748"],"Chromosome":"17","Position":"7217125-7225266","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Cardiomyopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"820.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Syncytiotrophoblasts":"722.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA019006","HPA020595"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"83000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 35: Non-specific - Mitochondria","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 39: Non-specific - Basic cellular processes","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA019006":"AB_1844478","HPA020595":"AB_1844479"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.88e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.68e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.25e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.50e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.90e-1"}},{"Gene":"ALDH18A1","Gene synonym":["GSAS","P5CS","PYCS","SPG9"],"Ensembl":"ENSG00000059573","Gene description":"Aldehyde dehydrogenase 18 family member A1","Uniprot":["P54886"],"Chromosome":"10","Position":"95605941-95656711","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Amino-acid biosynthesis","Proline biosynthesis"],"Molecular function":["Kinase","Multifunctional enzyme","Oxidoreductase","Transferase"],"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Intellectual disability","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"salivary gland":"116.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Distal enterocytes":"63.5","Proximal enterocytes":"67.2","Serous glandular cells":"67.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Spermatogonia","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA008333","HPA012604"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"49000","Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 48: Stomach - Proteolysis","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 75: Serous glandular cells - Salivary secretion","Interactions":25,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA008333":"AB_1078125","HPA012604":"AB_1844721"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.09e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.45e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.87e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.50e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.77e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.79e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.97e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.97e-3"}},{"Gene":"ALDH1B1","Gene synonym":["ALDH5","ALDHX"],"Ensembl":"ENSG00000137124","Gene description":"Aldehyde dehydrogenase 1 family member B1","Uniprot":["P30837"],"Chromosome":"9","Position":"38392702-38398661","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"167.4","smooth muscle":"123.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cholangiocytes":"66.8","Extravillous trophoblasts":"50.9","Hepatocytes":"114.7","Pancreatic endocrine cells":"54.3","Proximal tubular cells":"169.8","Undifferentiated cells":"82.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"vascular associated smooth muscle cell":"7.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Prostate - Smooth muscle cells","Skin - Smooth muscle cells","Spleen - Smooth muscle cells","Testis - Sertoli cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA021037","HPA077080"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"420000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 1: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 56: Proximal tubular cells - Amino acid metabolism","Interactions":19,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA021037":"AB_1844724","HPA077080":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.10e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.45e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.71e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.93e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.71e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.71e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.99e-6"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.82e-2"}},{"Gene":"ALDH1L2","Gene synonym":["FLJ38508","mtFDH"],"Ensembl":"ENSG00000136010","Gene description":"Aldehyde dehydrogenase 1 family member L2","Uniprot":["Q3SY69"],"Chromosome":"12","Position":"105019784-105107643","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["One-carbon metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"pancreas":"39.4","salivary gland":"12.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Early spermatids":"43.7","Excitatory neurons":"22.3","Inhibitory neurons":"23.1","Oligodendrocyte precursor cells":"23.6","Plasma cells":"27.4","Serous glandular cells":"38.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"39.5"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.26e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.67e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.42e-2"}},{"Gene":"ALDH4A1","Gene synonym":["ALDH4","P5CDh"],"Ensembl":"ENSG00000159423","Gene description":"Aldehyde dehydrogenase 4 family member A1","Uniprot":["P30038"],"Chromosome":"1","Position":"18871430-18902724","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Proline metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"193.4","liver":"426.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cytotrophoblasts":"78.7","Hepatocytes":"323.4","Proximal tubular cells":"255.4","Syncytiotrophoblasts":"81.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"astrocyte":"37.6","choroid plexus epithelial cell":"46.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":{"Liver Hepatocellular Carcinoma (TCGA)":"119.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB004645","HPA006401","HPA072759"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"30000","Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 1: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 38: Proximal tubular cells - Transmembrane transport","Interactions":18,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB004645":"AB_425775","HPA006401":"AB_1844731","HPA072759":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.74e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.95e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.22e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.73e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.62e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.35e-1"}},{"Gene":"ALDH5A1","Gene synonym":["SSADH","SSDH"],"Ensembl":"ENSG00000112294","Gene description":"Aldehyde dehydrogenase 5 family member A1","Uniprot":["P51649"],"Chromosome":"6","Position":"24494867-24537207","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"95.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cardiomyocytes":"39.9","Hepatocytes":"81.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"51.3"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Skeletal muscle - Skeletal myocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA029715","HPA029716"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"35000","Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 19: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 43: Hepatocytes - Metabolism","Interactions":5,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA029715":"AB_10599994","HPA029716":"AB_10601876"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.74e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.16e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.67e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.21e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.93e-1"}},{"Gene":"ALDH6A1","Gene synonym":["MMSDH"],"Ensembl":"ENSG00000119711","Gene description":"Aldehyde dehydrogenase 6 family member A1","Uniprot":["Q02252"],"Chromosome":"14","Position":"74056847-74084492","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"kidney":"365.2","liver":"355.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nTPM":{"Hepatocytes":"540.4","Proximal tubular cells":"777.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"43.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"43.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Spleen - Fibroblast_2","Testis - Sertoli cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA029072","HPA029073","HPA029074","HPA029075"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"26000","Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 1: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 56: Proximal tubular cells - Amino acid metabolism","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA029072":"AB_10599176","HPA029073":"AB_10601877","HPA029074":"AB_10601000","HPA029075":"AB_10602005"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.72e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.97e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.56e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.28e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.46e-2"}},{"Gene":"ALDH7A1","Gene synonym":["ATQ1","EPD","PDE"],"Ensembl":"ENSG00000164904","Gene description":"Aldehyde dehydrogenase 7 family member A1","Uniprot":["P49419"],"Chromosome":"5","Position":"126531200-126595362","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"157.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cytotrophoblasts":"455.7","Proximal tubular cells":"274.6","Syncytiotrophoblasts":"207.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"astrocyte":"240.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"6.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"6.3"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"301.3"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Skin - Mitotic cells (Skin)","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA023296","HPA053675"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"250000","Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 69: Liver - Oxidoreductase activity","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 24: Cytotrophoblasts - Mitochondria","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA023296":"AB_1844738","HPA053675":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.50e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.37e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.31e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.72e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.94e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.64e-1"}},{"Gene":"ALKBH3","Gene synonym":["DEPC-1"],"Ensembl":"ENSG00000166199","Gene description":"AlkB homolog 3, alpha-ketoglutarate dependent dioxygenase","Uniprot":["Q96Q83"],"Chromosome":"11","Position":"43880811-43920274","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Early spermatids":"64.8","Late spermatids":"111.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA009674","HPA046489"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 66: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 11: Late spermatids - Unknown function","Interactions":15,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA009674":"AB_1850460","HPA046489":"AB_2679671"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.49e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.21e-1"}},{"Gene":"BCKDHB","Gene synonym":[],"Ensembl":"ENSG00000083123","Gene description":"Branched chain keto acid dehydrogenase E1 subunit beta","Uniprot":["P21953"],"Chromosome":"6","Position":"80106647-80346270","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Maple syrup urine disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"75.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Astrocytes":"281.1","Early spermatids":"164.4","Oligodendrocytes":"94.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA031580","HPA031956"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 1: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 47: Astrocytes - Unknown function","Interactions":5,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA031580":"AB_10696054","HPA031956":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.22e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.41e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.93e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.29e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.01e-1"}},{"Gene":"BDH1","Gene synonym":["BDH","SDR9C1"],"Ensembl":"ENSG00000161267","Gene description":"3-hydroxybutyrate dehydrogenase 1","Uniprot":["Q02338"],"Chromosome":"3","Position":"197509783-197573323","Protein class":["Candidate cardiovascular disease genes","Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Allosteric enzyme","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"liver":"313.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Distal enterocytes":"96.6","Hepatocytes":"115.2","Proximal enterocytes":"83.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":{"Liver Hepatocellular Carcinoma (TCGA)":"78.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Prostate - Prostate glandular cells","Skeletal muscle - Skeletal myocytes","Spleen - B-cells (Spleen)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA030947","HPA058709"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 83: Liver - Metabolism","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 16: Intestinal goblet cells - Mucin production","Interactions":6,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA030947":"AB_10669548","HPA058709":"AB_2683797"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.26e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.80e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.98e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.04e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"CHDH","Gene synonym":[],"Ensembl":"ENSG00000016391","Gene description":"Choline dehydrogenase","Uniprot":["Q8NE62"],"Chromosome":"3","Position":"53812335-53846419","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"36.2","liver":"34.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Proximal enterocytes":"63.6","Proximal tubular cells":"72.6","Undifferentiated cells":"50.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"bergmann glia":"80.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"14","RNA blood cell specific nTPM":{"basophil":"3.0","T-reg":"1.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"18","RNA blood lineage specific nTPM":{"granulocytes":"3.0","T-cells":"1.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Skin - Eccrine sweat gland cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA036632","HPA036633","HPA058130"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 52: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 22: Proximal enterocytes - Digestion","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA036632":null,"HPA036633":"AB_10670841","HPA058130":"AB_2683615"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.74e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.43e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.03e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.12e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.37e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.30e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.46e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.50e-1"}},{"Gene":"CPOX","Gene synonym":["CPO","CPX","HCP"],"Ensembl":"ENSG00000080819","Gene description":"Coproporphyrinogen oxidase","Uniprot":["P36551"],"Chromosome":"3","Position":"98579446-98593648","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins"],"Biological process":["Heme biosynthesis","Porphyrin biosynthesis"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Hereditary hemolytic anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nTPM":{"Erythroid cells":"236.2","Extravillous trophoblasts":"79.5","Oligodendrocytes":"92.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nTPM":{"oligodendrocyte":"42.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA015736","HPA054448"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"100000","Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 5: Brain & Testis - Signal transduction","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 1: Erythroid cells - Oxygen transport","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA015736":"AB_1847194","HPA054448":"AB_2682490"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.65e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.75e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.08e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.10e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.95e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.01e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.28e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.51e-2"}},{"Gene":"CYB5R1","Gene synonym":["humb5R2","NQO3A2"],"Ensembl":"ENSG00000159348","Gene description":"Cytochrome b5 reductase 1","Uniprot":["Q9UHQ9"],"Chromosome":"1","Position":"202961873-202967275","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Steroid biosynthesis","Steroid metabolism","Sterol biosynthesis","Sterol metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"583.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cytotrophoblasts":"170.0","Extravillous trophoblasts":"224.4","Skeletal myocytes":"184.4","Syncytiotrophoblasts":"330.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Skin - Keratinocyte (other)","Stomach - Parietal cells","Testis - Sertoli cells","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA010531","HPA010641","HPA014147"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 14: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 4: Extravillous trophoblasts - Unknown function","Interactions":12,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA010531":null,"HPA010641":"AB_1078600","HPA014147":"AB_1847370"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.08e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.56e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.51e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.22e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.38e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.09e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.10e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.38e-3"}},{"Gene":"CYP11B1","Gene synonym":["CPN1","CYP11B","FHI","P450C11"],"Ensembl":"ENSG00000160882","Gene description":"Cytochrome P450 family 11 subfamily B member 1","Uniprot":["P15538"],"Chromosome":"8","Position":"142872356-142879846","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Steroid biosynthesis","Steroidogenesis"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":["Congenital adrenal hyperplasia","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"834","RNA tissue specific nTPM":{"adrenal gland":"3571.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"222","RNA single cell type specific nTPM":{"Early spermatids":"60.8","Late spermatids":"82.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA049171","HPA049565","HPA056348","HPA057752"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 36: Late spermatids - Unknown function","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA049171":"AB_2680661","HPA049565":null,"HPA056348":"AB_2683104","HPA057752":"AB_2683516"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CYP11B2","Gene synonym":["ALDOS","CPN2","CYP11B","CYP11BL","P-450C18","P450aldo"],"Ensembl":"ENSG00000179142","Gene description":"Cytochrome P450 family 11 subfamily B member 2","Uniprot":["P19099"],"Chromosome":"8","Position":"142910559-142917843","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism","Steroid metabolism","Steroidogenesis"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"941","RNA tissue specific nTPM":{"adrenal gland":"173.3"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":null,"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA049171","HPA049565","HPA056348","HPA057752"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Adrenal gland - Steroid metabolism","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":null,"Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA049171":"AB_2680661","HPA049565":null,"HPA056348":"AB_2683104","HPA057752":"AB_2683516"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB000355","HPA051194"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 58: Placenta - Pregnancy","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 50: Lymphoma - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CYP1B1","Gene synonym":["CP1B","GLC3A"],"Ensembl":"ENSG00000138061","Gene description":"Cytochrome P450 family 1 subfamily B member 1","Uniprot":["Q16678"],"Chromosome":"2","Position":"38066973-38109902","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism","Steroid metabolism"],"Molecular function":["Lyase","Monooxygenase","Oxidoreductase"],"Disease involvement":["Disease variant","Glaucoma","Peters anomaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Endometrial stromal cells":"100.6","Fibroblasts":"139.3","Leydig cells":"155.9","Macrophages":"120.3","Peritubular cells":"168.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nTPM":{"fibroblast":"507.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"classical monocyte":"157.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"24","RNA blood lineage specific nTPM":{"monocytes":"157.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.87e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.48e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.37e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.31e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.99e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.34e-5"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.23e-2"}},{"Gene":"CYP24A1","Gene synonym":["CP24","CYP24","lncBCAS1-4_1","P450-CC24"],"Ensembl":"ENSG00000019186","Gene description":"Cytochrome P450 family 24 subfamily A member 1","Uniprot":["Q07973"],"Chromosome":"20","Position":"54153446-54173986","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"endometrium 1":"14.5","kidney":"34.3","lymphoid tissue":"10.3","placenta":"9.7","urinary bladder":"27.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nTPM":{"Basal respiratory cells":"142.9","Basal squamous epithelial cells":"38.1","Ionocytes":"107.5","Proximal tubular cells":"65.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nTPM":{"endothelial cell":"8.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific FPKM":{"Bladder Urothelial Carcinoma (TCGA)":"26.3","Lung Adenocarcinoma (TCGA)":"32.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.29e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.22e-3"}},{"Gene":"CYP27A1","Gene synonym":["CP27","CTX","CYP27"],"Ensembl":"ENSG00000135929","Gene description":"Cytochrome P450 family 27 subfamily A member 1","Uniprot":["Q02318"],"Chromosome":"2","Position":"218781749-218815293","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cholesterol metabolism","Lipid biosynthesis","Lipid metabolism","Steroid biosynthesis","Steroid metabolism","Sterol metabolism"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":["Cataract","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"199.0","liver":"576.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Hepatocytes":"363.4","Hofbauer cells":"147.0","Proximal enterocytes":"194.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"choroid plexus epithelial cell":"168.2","oligodendrocyte":"201.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":{"Liver Hepatocellular Carcinoma (TCGA)":"287.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"classical monocyte":"151.6","neutrophil":"126.9"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"21","RNA blood lineage specific nTPM":{"granulocytes":"126.9","monocytes":"151.6"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"29.9","skin cancer":"65.6"},"RNA tissue cell type enrichment":["Heart muscle - Fibroblasts","Liver - Hepatocytes","Lung - Macrophages"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA059155"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 83: Liver - Metabolism","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 58: Macrophages - Innate immune response","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA059155":"AB_2683933"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.42e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.22e-8"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.15e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.03e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.05e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.88e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.44e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.31e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.85e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.84e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.94e-1"}},{"Gene":"CYP2E1","Gene synonym":["CYP2E"],"Ensembl":"ENSG00000130649","Gene description":"Cytochrome P450 family 2 subfamily E member 1","Uniprot":["P05181"],"Chromosome":"10","Position":"133520406-133561220","Protein class":["Cancer-related genes","Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"307","RNA tissue specific nTPM":{"liver":"10050.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"31","RNA single cell type specific nTPM":{"Hepatocytes":"6424.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"324","RNA cancer specific FPKM":{"Liver Hepatocellular Carcinoma (TCGA)":"1712.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"MAIT T-cell":"2.5","myeloid DC":"6.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"16","RNA blood lineage specific nTPM":{"dendritic cells":"6.3","T-cells":"2.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA009128","HPA029564"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 31: Liver - Plasma proteins","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 43: Hepatocytes - Metabolism","Interactions":2,"Subcellular main location":["Endoplasmic reticulum","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA009128":"AB_1078613","HPA029564":"AB_10602213"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.20e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.68e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.70e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.34e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.51e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.43e-1"}},{"Gene":"D2HGDH","Gene synonym":["D2HGD","FLJ42195","MGC25181"],"Ensembl":"ENSG00000180902","Gene description":"D-2-hydroxyglutarate dehydrogenase","Uniprot":["Q8N465"],"Chromosome":"2","Position":"241734602-241768816","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"2.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"B-cells":"2.5","T-cells":"1.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA056216","HPA060548"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 21: Testis - Unknown function","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 16: Intestinal goblet cells - Mucin production","Interactions":70,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA056216":"AB_2683070","HPA060548":"AB_2732650"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.15e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.17e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.92e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.49e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.90e-2"}},{"Gene":"DECR1","Gene synonym":["DECR","SDR18C1"],"Ensembl":"ENSG00000104325","Gene description":"2,4-dienoyl-CoA reductase 1","Uniprot":["Q16698"],"Chromosome":"8","Position":"90001405-90053633","Protein class":["Disease related genes","Enzymes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"280.7","liver":"265.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cardiomyocytes":"469.2","Proximal tubular cells":"459.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Skeletal muscle - Skeletal myocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA023160","HPA023162","HPA023238"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 43: Non-specific - Mitochondrial translation","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 39: Non-specific - Basic cellular processes","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA023160":"AB_1847585","HPA023162":"AB_1847586","HPA023238":"AB_1847587"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.18e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.75e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.24e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.06e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.16e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.59e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.64e-1"}},{"Gene":"DEGS1","Gene synonym":["DEGS-1","Des-1","DES1","FADS7","MLD"],"Ensembl":"ENSG00000143753","Gene description":"Delta 4-desaturase, sphingolipid 1","Uniprot":["O15121"],"Chromosome":"1","Position":"224175756-224193441","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins"],"Biological process":["Fatty acid biosynthesis","Fatty acid metabolism","Lipid biosynthesis","Lipid metabolism"],"Molecular function":["Isomerase","Oxidoreductase"],"Disease involvement":["Disease variant","Leukodystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"skin 1":"521.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cytotrophoblasts":"272.8","Suprabasal keratinocytes":"210.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Keratinocyte (other)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA076422"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 13: Skin - Cornification","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 24: Cytotrophoblasts - Mitochondria","Interactions":7,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA076422":"AB_2686799"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.32e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.48e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.63e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.45e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.17e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.95e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.19e-3"}},{"Gene":"DHFR","Gene synonym":[],"Ensembl":"ENSG00000228716","Gene description":"Dihydrofolate reductase","Uniprot":["P00374"],"Chromosome":"5","Position":"80626226-80654983","Protein class":["Cancer-related genes","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Methotrexate resistance","One-carbon metabolism"],"Molecular function":["Oxidoreductase","RNA-binding"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Erythroid cells":"146.0","Spermatocytes":"100.4","Undifferentiated cells":"69.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Liver - Hepatocytes","Spleen - Mitotic cells (Spleen)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB037129","HPA051465"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 67: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 52: Non-specific - Cell proliferation","Interactions":48,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB037129":"AB_439683","HPA051465":"AB_2681494"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.55e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.78e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.27e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.60e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.94e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"DHFR2","Gene synonym":["DHFRL1","DHFRP4","FLJ16119"],"Ensembl":"ENSG00000178700","Gene description":"Dihydrofolate reductase 2","Uniprot":["Q86XF0"],"Chromosome":"3","Position":"94047836-94063389","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["One-carbon metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Early spermatids":"55.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA051465"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 16: Non-specific - Transcription","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 18: Early spermatids - Unknown function","Interactions":11,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA051465":"AB_2681494"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.60e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.67e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.13e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.70e-3"}},{"Gene":"DHODH","Gene synonym":[],"Ensembl":"ENSG00000102967","Gene description":"Dihydroorotate dehydrogenase (quinone)","Uniprot":["Q02127"],"Chromosome":"16","Position":"72008588-72027664","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Pyrimidine biosynthesis"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"liver":"103.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Hepatocytes":"132.4","Lymphatic endothelial cells":"38.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA010123","HPA011942"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 83: Liver - Metabolism","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 62: Hepatocytes - Metabolism","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA010123":"AB_1847648","HPA011942":"AB_1847649"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.15e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.49e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.56e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.75e-5"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.44e-3"}},{"Gene":"DHRS3","Gene synonym":["RDH17","retSDR1","Rsdr1","SDR1","SDR16C1"],"Ensembl":"ENSG00000162496","Gene description":"Dehydrogenase\/reductase 3","Uniprot":["O75911"],"Chromosome":"1","Position":"12567910-12618210","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"315.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Late spermatids":"395.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nTPM":{"astrocyte":"70.8","central nervous system macrophage":"119.0","choroid plexus epithelial cell":"102.1","endothelial cell":"69.6","ependymal cell":"61.2","fibroblast":"57.2","leukocyte":"72.0","vascular associated smooth muscle cell":"50.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"gdT-cell":"87.0","MAIT T-cell":"63.2","memory CD4 T-cell":"47.0","memory CD8 T-cell":"41.0","myeloid DC":"24.1","naive CD4 T-cell":"79.4","naive CD8 T-cell":"50.2","NK-cell":"41.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"24.1","NK-cells":"41.2","T-cells":"87.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA010844"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Protein processing","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 63: Late spermatids - Spermatogenesis","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA010844":"AB_1847653"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.70e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.67e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.71e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.31e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.12e-2"}},{"Gene":"DLD","Gene synonym":["DLDH","E3","GCSL","LAD","OGDC-E3"],"Ensembl":"ENSG00000091140","Gene description":"Dihydrolipoamide dehydrogenase","Uniprot":["P09622"],"Chromosome":"7","Position":"107891162-107931730","Protein class":["Citric acid cycle related proteins","Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"222.4","tongue":"235.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cardiomyocytes":"342.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Liver - Hepatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA044849"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitochondria","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"11000000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 35: Non-specific - Mitochondria","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 39: Non-specific - Basic cellular processes","Interactions":48,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Principal piece"],"Antibody RRID":{"HPA044849":"AB_2679111"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.53e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.47e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.53e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.34e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.99e-3"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.88e-2"}},{"Gene":"DMGDH","Gene synonym":["ME2GLYDH"],"Ensembl":"ENSG00000132837","Gene description":"Dimethylglycine dehydrogenase","Uniprot":["Q9UI17"],"Chromosome":"5","Position":"78997564-79236038","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"kidney":"163.4","liver":"275.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Early spermatids":"45.4","Hepatocytes":"91.6","Late spermatids":"33.0","Proximal tubular cells":"58.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific FPKM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"32.2","Kidney Renal Papillary Cell Carcinoma (TCGA)":"13.9","Liver Hepatocellular Carcinoma (TCGA)":"28.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Adrenocortical cancer":"8.5","Kidney cancer":"9.2","liver cancer":"3.8"},"RNA tissue cell type enrichment":["Adrenal gland - 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Metabolism","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 56: Proximal tubular cells - Amino acid metabolism","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA036441":"AB_2675124","HPA036442":"AB_10669792","HPA077849":"AB_2686859"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.39e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.11e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.36e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.13e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.02e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - 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Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA041978","HPA058140"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - 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Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.61e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.53e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.25e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.93e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.64e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.55e-2"}},{"Gene":"ETHE1","Gene synonym":["HSCO","YF13H12"],"Ensembl":"ENSG00000105755","Gene description":"ETHE1 persulfide dioxygenase","Uniprot":["O95571"],"Chromosome":"19","Position":"43506719-43527230","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"247.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Distal enterocytes":"1734.4","Paneth cells":"661.4","Proximal enterocytes":"390.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA028360","HPA029028","HPA029029"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 45: Intestine - Digestion","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 5: Enterocytes - Absorption","Interactions":5,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA028360":"AB_10599297","HPA029028":"AB_10602092","HPA029029":"AB_10601998"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.86e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.75e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"FDXR","Gene synonym":["ADR","ADXR"],"Ensembl":"ENSG00000161513","Gene description":"Ferredoxin reductase","Uniprot":["P22570"],"Chromosome":"17","Position":"74862497-74873031","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cholesterol metabolism","Electron transport","Lipid metabolism","Steroid metabolism","Sterol metabolism","Transport"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Deafness","Disease variant","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"adrenal gland":"332.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Ciliated cells":"68.5","Granulosa cells":"175.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"ependymal cell":"24.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Keratinocyte (other)","Testis - Sertoli cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB008597","CAB009818","HPA044393","HPA053673"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 26: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 12: Squamous epithelial cells - Keratinization","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB008597":"AB_1615557","CAB009818":"AB_2102601","HPA044393":"AB_2678927","HPA053673":"AB_2682225"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.27e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.12e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.43e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.34e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.51e-1"}},{"Gene":"FXN","Gene synonym":["CyaY","FA","FARR","FRDA","X25"],"Ensembl":"ENSG00000165060","Gene description":"Frataxin","Uniprot":["Q16595"],"Chromosome":"9","Position":"69035751-69079076","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Heme biosynthesis","Ion transport","Iron storage","Iron transport","Transport"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Hepatocytes":"79.8","Oocytes":"67.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB022164","HPA068304"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 56: Non-specific - Unknown function","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 1: Erythroid cells - Oxygen transport","Interactions":10,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB022164":null,"HPA068304":"AB_2685970"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.34e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.78e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.08e-2"}},{"Gene":"GCDH","Gene synonym":["ACAD5","GCD"],"Ensembl":"ENSG00000105607","Gene description":"Glutaryl-CoA dehydrogenase","Uniprot":["Q92947"],"Chromosome":"19","Position":"12891160-12914207","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Glutaricaciduria"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"86.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Hepatocytes":"125.6","Proximal tubular cells":"143.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Liver - Hepatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA043252","HPA048492"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 83: Liver - Metabolism","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Proximal tubular cells - Amino acid metabolism","Interactions":6,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA043252":"AB_2678390","HPA048492":"AB_2680418"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.70e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.74e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.29e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.36e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.92e-2"}},{"Gene":"GFER","Gene synonym":["ALR","ERV1","HERV1","HPO1","HPO2","HSS"],"Ensembl":"ENSG00000127554","Gene description":"Growth factor, augmenter of liver regeneration","Uniprot":["P55789"],"Chromosome":"16","Position":"1984193-1987749","Protein class":["Disease related genes","Enzymes","Potential drug targets","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Growth factor","Oxidoreductase"],"Disease involvement":["Cataract","Deafness","Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Distal enterocytes":"170.5","Late spermatids":"156.0","Proximal enterocytes":"393.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA041227","HPA063553"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":"Secreted to blood","Secretome function":"Growth factor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 78: Testis - Transcription","Brain expression cluster":"Cluster 26: Oligodendrocytes - 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Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.51e-2"}},{"Gene":"GLDC","Gene synonym":["GCSP","NKH"],"Ensembl":"ENSG00000178445","Gene description":"Glycine decarboxylase","Uniprot":["P23378"],"Chromosome":"9","Position":"6532467-6645729","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"liver":"169.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cytotrophoblasts":"82.0","Extravillous trophoblasts":"39.2","Hepatocytes":"78.7","Oligodendrocyte precursor cells":"49.1","Syncytiotrophoblasts":"35.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"oligodendrocyte precursor cell":"71.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific FPKM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"89.4","Testicular Germ Cell Tumor (TCGA)":"146.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"39.3"},"RNA tissue cell type enrichment":["Breast - Plasma cells","Kidney - Proximal tubular cells","Minor Salivary Gland - Plasma cells","Skin - Sebaceous gland cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA002318","HPA052887"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"360000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 24: Cytotrophoblasts - Mitochondria","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA002318":"AB_1849700","HPA052887":"AB_2681980"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.23e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.27e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.16e-2"}},{"Gene":"GLUD1","Gene synonym":["GDH","GDH1","GLUD","hGDH1"],"Ensembl":"ENSG00000148672","Gene description":"Glutamate dehydrogenase 1","Uniprot":["P00367"],"Chromosome":"10","Position":"87050202-87094843","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"303.2","kidney":"273.8","liver":"892.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Astrocytes":"279.0","Hepatocytes":"375.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"astrocyte":"607.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Fibroblasts","Kidney - Proximal tubular cells","Liver - Hepatocytes","Prostate - Prostate glandular cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA042492","HPA044839","HPA061369"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 69: Liver - Oxidoreductase activity","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 78: NK-cells & T-cells - Immune system & Transcription","Interactions":39,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA042492":"AB_2678024","HPA044839":"AB_2679107","HPA061369":"AB_2684494"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.54e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.14e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.53e-2"}},{"Gene":"GLUD2","Gene synonym":["GLUDP1"],"Ensembl":"ENSG00000182890","Gene description":"Glutamate dehydrogenase 2","Uniprot":["P49448"],"Chromosome":"X","Position":"121047610-121050094","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"liver":"3.8","testis":"15.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Astrocytes":"2.2","Cytotrophoblasts":"4.3","Distal tubular cells":"3.1","Proximal tubular cells":"2.1","Sertoli cells":"5.4","Syncytiotrophoblasts":"2.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific FPKM":{"Liver Hepatocellular Carcinoma (TCGA)":"2.0","Skin Cuteneous Melanoma (TCGA)":"2.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"3.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA008012","HPA045506"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"600000","Blood expression cluster":"Cluster 26: Monocytes - Plasma membrane proteins","Tissue expression cluster":"Cluster 79: Non-specific - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.66e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.61e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.38e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.05e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.05e-2"}},{"Gene":"GPX4","Gene synonym":["MCSP","PHGPx"],"Ensembl":"ENSG00000167468","Gene description":"Glutathione peroxidase 4","Uniprot":["P36969"],"Chromosome":"19","Position":"1103982-1106791","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Developmental protein","Oxidoreductase","Peroxidase"],"Disease involvement":["Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"5","RNA single cell type specific nTPM":{"Late spermatids":"18077.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.44e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.53e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.10e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.76e-2"}},{"Gene":"HADH","Gene synonym":["HADH1","HADHSC","SCHAD"],"Ensembl":"ENSG00000138796","Gene description":"Hydroxyacyl-CoA dehydrogenase","Uniprot":["Q16836"],"Chromosome":"4","Position":"107989714-108035241","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Oxidoreductase","Transferase"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cardiomyocytes":"288.6","Hepatocytes":"310.8","Proximal enterocytes":"386.9","Proximal tubular cells":"250.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Skeletal muscle - Skeletal myocytes","Skin - Sebaceous gland cells","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA039588","HPA043888"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"830000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 35: Non-specific - Mitochondria","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 22: Proximal enterocytes - Digestion","Interactions":6,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA039588":"AB_10673425","HPA043888":"AB_2678716"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.02e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.60e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.12e-13"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.87e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.29e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.60e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.80e-2"}},{"Gene":"HADHA","Gene synonym":["GBP","LCEH","LCHAD","MTPA"],"Ensembl":"ENSG00000084754","Gene description":"Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha","Uniprot":["P40939"],"Chromosome":"2","Position":"26190635-26244672","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Lyase","Multifunctional enzyme","Oxidoreductase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"484.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Proximal enterocytes":"500.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA015536","HPA056070"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"530000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 12: Heart muscle - Cardiac muscle contraction","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 5: Enterocytes - Absorption","Interactions":75,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA015536":"AB_1850473","HPA056070":"AB_2683026"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.47e-7"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.03e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.15e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.90e-3"}},{"Gene":"IDH2","Gene synonym":["IDH-2"],"Ensembl":"ENSG00000182054","Gene description":"Isocitrate dehydrogenase (NADP(+)) 2","Uniprot":["P48735"],"Chromosome":"15","Position":"90083045-90102477","Protein class":["Cancer-related genes","Citric acid cycle related proteins","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Glyoxylate bypass","Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"heart muscle":"476.6","skeletal muscle":"1256.7","tongue":"1548.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cardiomyocytes":"567.2","Cytotrophoblasts":"742.0","Distal tubular cells":"934.3","Extravillous trophoblasts":"653.5","Syncytiotrophoblasts":"607.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Colon - Smooth muscle cells","Heart muscle - Cardiomyocytes","Lung - Mitotic cells (Lung)","Skeletal muscle - Skeletal myocytes","Spleen - Mitotic cells (Spleen)","Stomach - Parietal cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA007831"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6000000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 35: Non-specific - Mitochondria","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 24: Cytotrophoblasts - Mitochondria","Interactions":23,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA007831":"AB_1851397"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.19e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.39e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.70e-2"}},{"Gene":"IDH3A","Gene synonym":[],"Ensembl":"ENSG00000166411","Gene description":"Isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha","Uniprot":["P50213"],"Chromosome":"15","Position":"78131498-78171945","Protein class":["Citric acid cycle related proteins","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","FDA approved drug targets","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"tongue":"95.4"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"144.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA041465","HPA062971"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"25000","Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 35: Non-specific - Mitochondria","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 8: Neurons - Neuronal signaling","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA041465":"AB_10794377","HPA062971":"AB_2684913"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.98e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.32e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.71e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.88e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.14e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.95e-3"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.14e-1"}},{"Gene":"IVD","Gene synonym":["ACAD2","IVDH"],"Ensembl":"ENSG00000128928","Gene description":"Isovaleryl-CoA dehydrogenase","Uniprot":["P26440"],"Chromosome":"15","Position":"40405485-40435947","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Hepatocytes":"130.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA041391","HPA044250"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 26: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 3: Basal prostatic cells - Lipid metabolism","Interactions":19,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA041391":"AB_2677449","HPA044250":"AB_2678875"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.01e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.89e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.90e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.37e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.30e-2"}},{"Gene":"L2HGDH","Gene synonym":["C14orf160","FLJ12618"],"Ensembl":"ENSG00000087299","Gene description":"L-2-hydroxyglutarate dehydrogenase","Uniprot":["Q9H9P8"],"Chromosome":"14","Position":"50237563-50312229","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Early spermatids":"44.4","Excitatory neurons":"58.6","Inhibitory neurons":"58.9","Rod photoreceptor cells":"42.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"8.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Skin - Keratinocyte (other)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA065409","HPA069708"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 19: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 65: Neurons - Synaptic function","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA065409":"AB_2685485","HPA069708":"AB_2686179"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.68e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.26e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.51e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.98e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.82e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.66e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.49e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.77e-1"}},{"Gene":"MAOA","Gene synonym":[],"Ensembl":"ENSG00000189221","Gene description":"Monoamine oxidase A","Uniprot":["P21397"],"Chromosome":"X","Position":"43654907-43746817","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Catecholamine metabolism","Neurotransmitter degradation"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","FDA approved drug targets","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"213.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Distal enterocytes":"309.6","Proximal enterocytes":"817.1","Proximal tubular cells":"517.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"endothelial cell":"246.7","pericyte":"107.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"47.6","prostate cancer":"69.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Breast - Adipocytes (Breast)","Spleen - Fibroblast_2","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB009437","HPA054807","HPA059299"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 55: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 22: Proximal enterocytes - Digestion","Interactions":3,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB009437":"AB_2137260","HPA054807":"AB_2682607","HPA059299":"AB_2683970"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.21e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.94e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.34e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.14e-4"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.24e-1"}},{"Gene":"MDH2","Gene synonym":[],"Ensembl":"ENSG00000146701","Gene description":"Malate dehydrogenase 2","Uniprot":["P40926"],"Chromosome":"7","Position":"76048051-76067508","Protein class":["Citric acid cycle related proteins","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Epilepsy","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"672.4","tongue":"578.8"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA019714","HPA019716","HPA019848","HPA026720"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"10000000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 12: Heart muscle - Cardiac muscle contraction","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 39: Non-specific - Basic cellular processes","Interactions":41,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA019714":"AB_1853678","HPA019716":"AB_1853680","HPA019848":"AB_1853683","HPA026720":"AB_1853685"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.59e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.21e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.53e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.40e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.87e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.17e-2"}},{"Gene":"ME2","Gene synonym":[],"Ensembl":"ENSG00000082212","Gene description":"Malic enzyme 2","Uniprot":["P23368"],"Chromosome":"18","Position":"50879080-50954257","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Allosteric enzyme","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"88.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cardiomyocytes":"158.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"choroid plexus epithelial cell":"405.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"choroid plexus":"107.9"},"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Macrophages"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA008247","HPA008880"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"150000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 60: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 58: Macrophages - Innate immune response","Interactions":6,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA008247":"AB_1853704","HPA008880":"AB_1853702"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.41e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.01e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.94e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.83e-1"}},{"Gene":"MECR","Gene synonym":["CGI-63","ETR1","FASN2B","NRBF1"],"Ensembl":"ENSG00000116353","Gene description":"Mitochondrial trans-2-enoyl-CoA reductase","Uniprot":["Q9BV79"],"Chromosome":"1","Position":"29192657-29230942","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Fatty acid biosynthesis","Fatty acid metabolism","Lipid biosynthesis","Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Dystonia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Late spermatids":"84.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Skin - Sebaceous gland cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA022018","HPA022030","HPA028740"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 54: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 66: Photoreceptor cells - Visual perception","Interactions":3,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA022018":"AB_1853714","HPA022030":"AB_1853716","HPA028740":"AB_10601133"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.66e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.42e-3"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.47e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.34e-1"}},{"Gene":"MTHFD2","Gene synonym":[],"Ensembl":"ENSG00000065911","Gene description":"Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase","Uniprot":["P13995"],"Chromosome":"2","Position":"74186172-74217565","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["One-carbon metabolism"],"Molecular function":["Hydrolase","Multifunctional enzyme","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Langerhans cells":"275.1","Smooth muscle cells":"162.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"central nervous system macrophage":"47.7","vascular associated smooth muscle cell":"35.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB003684","HPA049657"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 18: Non-specific - Ribosome","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 48: Smooth muscle cells - Signal transduction","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB003684":"AB_425867","HPA049657":"AB_2680842"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.08e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.10e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.70e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.69e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.55e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.93e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.20e-11"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.33e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.38e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.83e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.63e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"OGDH","Gene synonym":["E1k","KGD1","OGDC-E1","OGDH2"],"Ensembl":"ENSG00000105953","Gene description":"Oxoglutarate dehydrogenase","Uniprot":["Q02218"],"Chromosome":"7","Position":"44606572-44709066","Protein class":["Citric acid cycle related proteins","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Glycolysis"],"Molecular function":["Oxidoreductase"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"313.4","skeletal muscle":"350.8","tongue":"360.2"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA019514","HPA020347"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"89000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 23: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 29: Monocytes - Innate immune response","Interactions":19,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA019514":"AB_1854772","HPA020347":"AB_1854773"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.14e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.51e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.14e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.63e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.65e-2"}},{"Gene":"P4HA1","Gene synonym":["C-P4Halpha(I)","P4HA"],"Ensembl":"ENSG00000122884","Gene description":"Prolyl 4-hydroxylase subunit alpha 1","Uniprot":["P13674"],"Chromosome":"10","Position":"73007217-73096974","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA007599","HPA026593"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Vesicles","Mitochondria"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"120000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 19: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 35: Respiratory epithelial cells - Unknown function","Interactions":48,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Vesicles","Mitochondria"],"Antibody RRID":{"HPA007599":"AB_1854891","HPA026593":"AB_1854892"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.08e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.66e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.75e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.61e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.92e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.34e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.54e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.49e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.14e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.43e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.86e-2"}},{"Gene":"PDHA1","Gene synonym":["E1alpha","PDHA"],"Ensembl":"ENSG00000131828","Gene description":"Pyruvate dehydrogenase E1 subunit alpha 1","Uniprot":["P08559"],"Chromosome":"X","Position":"19343893-19361718","Protein class":["Citric acid cycle related proteins","Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism","Glucose metabolism","Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Leigh syndrome","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"247.3","skeletal muscle":"215.3","tongue":"432.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cardiomyocytes":"650.8","Oocytes":"506.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Skin - Sebaceous gland cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA047487","HPA047864","HPA063053"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"49000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 35: Non-specific - Mitochondria","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 36: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 68: Cardiomyocytes - Muscle contraction","Interactions":111,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA047487":"AB_2680066","HPA047864":"AB_2680190","HPA063053":"AB_2684931"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.69e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.39e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.79e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.09e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.01e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.47e-1"}},{"Gene":"PDHA2","Gene synonym":["PDHAL"],"Ensembl":"ENSG00000163114","Gene description":"Pyruvate dehydrogenase E1 subunit alpha 2","Uniprot":["P29803"],"Chromosome":"4","Position":"95840093-95841464","Protein class":["Citric acid cycle related proteins","Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism","Glucose metabolism","Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"585","RNA tissue specific nTPM":{"testis":"58.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"29","RNA single cell type specific nTPM":{"Early spermatids":"473.0","Late spermatids":"305.4","Spermatocytes":"188.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PDHB","Gene synonym":["E1beta","PDHE1B"],"Ensembl":"ENSG00000168291","Gene description":"Pyruvate dehydrogenase E1 subunit beta","Uniprot":["P11177"],"Chromosome":"3","Position":"58427630-58433857","Protein class":["Citric acid cycle related proteins","Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism","Glucose metabolism","Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"tongue":"287.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cardiomyocytes":"371.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Colon - Smooth muscle cells","Heart muscle - Cardiomyocytes","Testis - Spermatocytes","Testis - Spermatogonia"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB033794","HPA036744","HPA036745"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"37000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 35: Non-specific - Mitochondria","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 68: Cardiomyocytes - Muscle contraction","Interactions":38,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB033794":"AB_2162946","HPA036744":"AB_10670921","HPA036745":"AB_2675285"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.44e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.15e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.18e-1"}},{"Gene":"PPOX","Gene synonym":["PPO","VP"],"Ensembl":"ENSG00000143224","Gene description":"Protoporphyrinogen oxidase","Uniprot":["P50336"],"Chromosome":"1","Position":"161166056-161178013","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Heme biosynthesis","Porphyrin biosynthesis"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Ciliated cells":"66.2","Erythroid cells":"59.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Skeletal muscle - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA030123"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 5: Brain & Testis - Signal transduction","Brain expression cluster":"Cluster 55: Non-specific - 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Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.39e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.32e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - 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Macrophages"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB004682","HPA007730"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 54: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - 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Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.30e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.86e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.28e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.14e-1"}},{"Gene":"PRDX3","Gene synonym":["AOP-1","AOP1","MER5","SP-22"],"Ensembl":"ENSG00000165672","Gene description":"Peroxiredoxin 3","Uniprot":["P30048"],"Chromosome":"10","Position":"119167720-119178812","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Antioxidant","Oxidoreductase","Peroxidase"],"Disease involvement":["Corneal dystrophy","Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Distal tubular cells":"731.5","Proximal tubular cells":"841.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Colon - Smooth muscle cells","Liver - Hepatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB008656","HPA041488","HPA063551","CAB079909"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1700000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 1: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 39: Non-specific - Basic cellular processes","Interactions":25,"Subcellular main location":["Vesicles","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB008656":"AB_1620979","CAB079909":"AB_2809998","HPA041488":"AB_2677508","HPA063551":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.59e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.74e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.30e-1"}},{"Gene":"PRDX5","Gene synonym":["ACR1","AOEB166","B166","MGC117264","MGC142283","MGC142285","PLP","PMP20","PRDX6","PRXV","SBBI10"],"Ensembl":"ENSG00000126432","Gene description":"Peroxiredoxin 5","Uniprot":["P30044"],"Chromosome":"11","Position":"64318121-64321811","Protein class":["Enzymes","FDA approved drug targets","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Antioxidant","Oxidoreductase","Peroxidase"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"1360.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Ciliated cells":"1873.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"ependymal cell":"214.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB008661","HPA037915","HPA037916"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7500000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 23: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 42: Ciliated cells - Cilium assembly","Interactions":17,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB008661":"AB_1620988","HPA037915":"AB_2675735","HPA037916":"AB_2675736"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.09e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.20e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.13e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.32e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.50e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.76e-2"}},{"Gene":"PRODH","Gene synonym":["HSPOX2","PIG6","PRODH1","PRODH2","TP53I6"],"Ensembl":"ENSG00000100033","Gene description":"Proline dehydrogenase 1","Uniprot":["O43272"],"Chromosome":"22","Position":"18912777-18936553","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Proline metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Schizophrenia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"55.6","choroid plexus":"65.5","skeletal muscle":"47.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"10","RNA single cell type specific nTPM":{"Astrocytes":"173.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nTPM":{"astrocyte":"13.8","bergmann glia":"8.7","choroid plexus epithelial cell":"9.4"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific FPKM":{"Testicular Germ Cell Tumor (TCGA)":"25.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"9.2"},"RNA tissue cell type enrichment":["Adipose visceral - 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Unknown function","Single cell expression cluster":"Cluster 47: Astrocytes - Unknown function","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA020361":"AB_10963116"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.68e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.20e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.67e-2"}},{"Gene":"PYCR2","Gene synonym":["P5CR2"],"Ensembl":"ENSG00000143811","Gene description":"Pyrroline-5-carboxylate reductase 2","Uniprot":["Q96C36"],"Chromosome":"1","Position":"225919877-225924340","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Amino-acid biosynthesis","Proline biosynthesis"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Leukodystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Pituitary gland - Undifferentiated cells (Pituitary gland)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA056873"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 54: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 22: Non-specific - 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Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.93e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.54e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.76e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.65e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.30e-1"}},{"Gene":"QDPR","Gene synonym":["DHPR","PKU2","SDR33C1"],"Ensembl":"ENSG00000151552","Gene description":"Quinoid dihydropteridine reductase","Uniprot":["P09417"],"Chromosome":"4","Position":"17460261-17512206","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Tetrahydrobiopterin biosynthesis"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Phenylketonuria"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"707.1","liver":"190.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Hepatocytes":"377.8","Muller glia cells":"374.1","Oligodendrocytes":"448.0","Proximal tubular cells":"393.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nTPM":{"committed oligodendrocyte precursor":"252.1","oligodendrocyte":"754.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Pituitary gland - Thyrotropes","Prostate - Prostate glandular cells","Skin - Eccrine sweat gland cells","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA058951","HPA065649"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2300000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 9: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 56: Proximal tubular cells - Amino acid metabolism","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA058951":"AB_2683861","HPA065649":"AB_2685526"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.57e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.81e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.84e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.41e-2"}},{"Gene":"RDH13","Gene synonym":["SDR7C3"],"Ensembl":"ENSG00000160439","Gene description":"Retinol dehydrogenase 13","Uniprot":["Q8NBN7"],"Chromosome":"19","Position":"55039108-55071291","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"5","RNA single cell type specific nTPM":{"Syncytiotrophoblasts":"242.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Stomach - Gastric mucous cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA042006"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 27: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Syncytiotrophoblasts - Pregnancy","Interactions":9,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042006":"AB_10960270"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.32e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.19e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.90e-2"}},{"Gene":"SARDH","Gene synonym":["DMGDHL1","SDH"],"Ensembl":"ENSG00000123453","Gene description":"Sarcosine dehydrogenase","Uniprot":["Q9UL12"],"Chromosome":"9","Position":"133663560-133739955","Protein class":["Disease related genes","Enzymes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"epididymis":"40.6","liver":"76.3","pancreas":"40.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nTPM":{"Hepatocytes":"108.1","Oocytes":"74.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":{"mammillary body":"15.0"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific FPKM":{"Liver Hepatocellular Carcinoma (TCGA)":"35.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"memory CD4 T-cell":"3.2","naive CD4 T-cell":"6.5","T-reg":"8.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"T-cells":"8.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells","Kidney - Proximal tubular cells","Liver - Hepatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA057267","HPA058086"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"160000","Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 53: Non-specific - Glycosylation","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 43: Hepatocytes - Metabolism","Interactions":20,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA057267":"AB_2683388","HPA058086":"AB_2683601"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.85e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.58e-4"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.60e-2"}},{"Gene":"SDHA","Gene synonym":["FP","SDH2","SDHF"],"Ensembl":"ENSG00000073578","Gene description":"Succinate dehydrogenase complex flavoprotein subunit A","Uniprot":["P31040"],"Chromosome":"5","Position":"218303-257082","Protein class":["Cancer-related genes","Citric acid cycle related proteins","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Electron transport","Transport","Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Cancer-related genes","Cardiomyopathy","Disease variant","FDA approved drug targets","Leigh syndrome","Neurodegeneration","Primary mitochondrial disease","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"554.8","skeletal muscle":"459.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cardiomyocytes":"453.4","Proximal enterocytes":"257.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB034929","HPA041981","HPA064582"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"240000","Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 23: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 68: Cardiomyocytes - Muscle contraction","Interactions":48,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"CAB034929":"AB_2183443","HPA041981":"AB_2677779","HPA064582":"AB_2685293"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.59e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.54e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.10e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.29e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.12e-1"}},{"Gene":"SDHB","Gene synonym":["SDH","SDH1"],"Ensembl":"ENSG00000117118","Gene description":"Succinate dehydrogenase complex iron sulfur subunit B","Uniprot":["P21912"],"Chromosome":"1","Position":"17018722-17054032","Protein class":["Cancer-related genes","Citric acid cycle related proteins","Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Electron transport","Host-virus interaction","Transport","Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Cancer-related genes","Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"474.3","tongue":"557.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cardiomyocytes":"573.9","Proximal tubular cells":"391.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Spleen - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA002868","CAB009822","CAB068233","CAB068234","CAB068235"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3600","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 35: Non-specific - Mitochondria","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 15: Non-specific - Mixed function","Interactions":26,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"CAB009822":"AB_2183458","CAB068233":"AB_2665638","CAB068234":"AB_2665639","CAB068235":"AB_2665640","HPA002868":"AB_1079889"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.85e-5"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.81e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.45e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.88e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.44e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.58e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.53e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.36e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.46e-1"}},{"Gene":"SOD2","Gene synonym":["GC1","GClnc1","IPOB","MnSOD"],"Ensembl":"ENSG00000291237","Gene description":"Superoxide dismutase 2","Uniprot":["P04179"],"Chromosome":"6","Position":"159669069-159762529","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"1069.8"},"RNA single cell type specificity":null,"RNA single cell type distribution":null,"RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA single nuclei brain specificity":null,"RNA single nuclei brain distribution":null,"RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":null,"RNA cancer distribution":null,"RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"neutrophil":"4504.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"granulocytes":"4504.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA001814"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"37000000","Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":null,"Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":null,"Interactions":8,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA001814":"AB_1080134"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SQOR","Gene synonym":["CGI-44","SQR","SQRDL"],"Ensembl":"ENSG00000137767","Gene description":"Sulfide quinone oxidoreductase","Uniprot":["Q9Y6N5"],"Chromosome":"15","Position":"45631148-45691281","Protein class":["Disease related genes","Enzymes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"203.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Basal respiratory cells":"185.4","Distal enterocytes":"448.5"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nTPM":{"central nervous system macrophage":"53.3","endothelial cell":"38.0","fibroblast":"18.8","leukocyte":"42.3","pericyte":"18.3","vascular associated smooth muscle cell":"23.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Macrophages"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA017079","HPA041589"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 75: Epithelium - Extracellular exosomes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 5: Enterocytes - Absorption","Interactions":6,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA017079":"AB_1857467","HPA041589":"AB_2677565"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.01e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.83e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.68e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.69e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.73e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.69e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.66e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.07e-2"}},{"Gene":"TMLHE","Gene synonym":["BBOX2","FLJ10727","TMLH","XAP130"],"Ensembl":"ENSG00000185973","Gene description":"Trimethyllysine hydroxylase, epsilon","Uniprot":["Q9NVH6"],"Chromosome":"X","Position":"155489011-155719098","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Carnitine biosynthesis"],"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":["Autism","Autism spectrum disorder","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Microglial cells":"49.2","Oligodendrocyte precursor cells":"44.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Skin - Mitotic cells (Skin)"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA034589","HPA040331"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 35: Non-specific - Mitochondria","Brain expression cluster":"Cluster 25: Non-specific - 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Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.64e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.20e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.76e-1"}},{"Gene":"TXNRD2","Gene synonym":["SELZ","TR","TR3","TRXR2"],"Ensembl":"ENSG00000184470","Gene description":"Thioredoxin reductase 2","Uniprot":["Q9NNW7"],"Chromosome":"22","Position":"19875517-19941820","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Prostatic glandular cells":"74.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Prostate - Prostate glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB002007","HPA003323"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2300000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 43: Non-specific - Mitochondrial translation","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 24: Cytotrophoblasts - Mitochondria","Interactions":4,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB002007":null,"HPA003323":"AB_1080396"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.86e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.54e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.97e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"TYW5","Gene synonym":["C2orf60","FLJ37953"],"Ensembl":"ENSG00000162971","Gene description":"TRNA-yW synthesizing protein 5","Uniprot":["A2RUC4"],"Chromosome":"2","Position":"199928913-199955736","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cone photoreceptor cells":"79.9","Rod photoreceptor cells":"61.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA045803"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 40: Non-specific - Transcription","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 10: Muller glia cells - Visual perception","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA045803":"AB_10964878"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.43e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.51e-1"}}]