Gene	"Gene synonym"	Ensembl	"Gene description"	Uniprot	Chromosome	Position	"Protein class"	"Biological process"	"Molecular function"	"Disease involvement"	Evidence	"HPA evidence"	"UniProt evidence"	"NeXtProt evidence"	"RNA tissue specificity"	"RNA tissue distribution"	"RNA tissue specificity score"	"RNA tissue specific nTPM"	"RNA single cell type specificity"	"RNA single cell type distribution"	"RNA single cell type specificity score"	"RNA single cell type specific nCPM"	"RNA single nuclei brain specificity"	"RNA single nuclei brain distribution"	"RNA single nuclei brain specificity score"	"RNA single nuclei brain specific nCPM"	"RNA cancer specificity"	"RNA cancer distribution"	"RNA cancer specificity score"	"RNA cancer specific pTPM"	"RNA brain regional specificity"	"RNA brain regional distribution"	"RNA brain regional specificity score"	"RNA brain regional specific nTPM"	"RNA blood cell specificity"	"RNA blood cell distribution"	"RNA blood cell specificity score"	"RNA blood cell specific nTPM"	"RNA blood lineage specificity"	"RNA blood lineage distribution"	"RNA blood lineage specificity score"	"RNA blood lineage specific nTPM"	"RNA cell line specificity"	"RNA cell line distribution"	"RNA cell line specificity score"	"RNA cell line specific nTPM"	"RNA tissue cell type enrichment"	"RNA mouse brain regional specificity"	"RNA mouse brain regional distribution"	"RNA mouse brain regional specificity score"	"RNA mouse brain regional specific nTPM"	"RNA pig brain regional specificity"	"RNA pig brain regional distribution"	"RNA pig brain regional specificity score"	"RNA pig brain regional specific nTPM"	Antibody	"Reliability (IH)"	"Reliability (Mouse Brain)"	"Reliability (IF)"	"Subcellular location"	"Secretome location"	"Secretome function"	"CCD Protein"	"CCD Transcript"	"Blood concentration - Conc. blood IM [pg/L]"	"Blood concentration - Conc. blood MS [pg/L]"	"Blood expression cluster"	"Tissue expression cluster"	"Brain expression cluster"	"Cell line expression cluster"	"Single cell expression cluster"	Interactions	"Subcellular main location"	"Subcellular additional location"	"Antibody RRID"	"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)"	"Cancer prognostics - Breast Invasive Carcinoma (TCGA)"	"Cancer prognostics - Breast Invasive Carcinoma (validation)"	"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)"	"Cancer prognostics - Colon Adenocarcinoma (TCGA)"	"Cancer prognostics - Colon Adenocarcinoma (validation)"	"Cancer prognostics - Glioblastoma Multiforme (TCGA)"	"Cancer prognostics - Glioblastoma Multiforme (validation)"	"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)"	"Cancer prognostics - Kidney Chromophobe (TCGA)"	"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)"	"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)"	"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)"	"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)"	"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)"	"Cancer prognostics - Lung Adenocarcinoma (TCGA)"	"Cancer prognostics - Lung Adenocarcinoma (validation)"	"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)"	"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)"	"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)"	"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)"	"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)"	"Cancer prognostics - Pancreatic Adenocarcinoma (validation)"	"Cancer prognostics - Prostate Adenocarcinoma (TCGA)"	"Cancer prognostics - Rectum Adenocarcinoma (TCGA)"	"Cancer prognostics - Rectum Adenocarcinoma (validation)"	"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)"	"Cancer prognostics - Stomach Adenocarcinoma (TCGA)"	"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)"	"Cancer prognostics - Thyroid Carcinoma (TCGA)"	"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)"
PYCARD	"ASC, CARD5, TMS-1"	ENSG00000103490	"PYD and CARD domain containing"	Q9ULZ3	16	31201486-31203450	"Predicted intracellular proteins"	"Apoptosis, Immunity, Inflammatory response, Innate immunity"		"Tumor suppressor"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in many"		"lymphoid tissue: 104.6;skin 1: 111.0"	"Cell type enhanced"	"Detected in many"		"cDC: 266.3;Colonocytes: 227.6;Enteric transient amplifying cells: 295.7;Enterocytes: 430.6;Esophageal basal cells: 257.9;Esophageal suprabasal cells: 328.6;Hofbauer cells: 539.7;Kupffer cells: 448.9;Macrophages: 223.7;Monocyte progenitors: 272.5;monocytes: 363.4;Neutrophils: 327.8;pDCs: 231.8"	"Group enriched"	"Detected in some"	5	"central nervous system macrophage: 49.0;leukocyte: 32.9"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Group enriched"	"Detected in all"	5	"basophil: 588.9;classical monocyte: 1101.6;eosinophil: 950.8;intermediate monocyte: 1140.1;myeloid DC: 830.8;neutrophil: 1647.4;non-classical monocyte: 1158.7;plasmacytoid DC: 771.2"	"Group enriched"	"Detected in all"	6	"dendritic cells: 830.8;granulocytes: 1647.4;monocytes: 1158.7"	"Low cancer specificity"	"Detected in many"			"Adrenal gland - Macrophages, Lung - Macrophages, Minor Salivary Gland - Mitotic cells (Minor salivary gland), Skin - Keratinocyte (other)"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB006853, CAB015948, HPA049074, HPA054496"	Enhanced		Supported	Nucleoplasm,Nucleoli,Cytosol			NA	NA		390000	"Cluster 7: Non-specific - Innate immune response"	"Cluster 5: Spleen - Immune response"	"Cluster 20: Macrophages & Microglia - Immune response"	"Cluster 14: Myeloid leukemia - Innate immune response"	"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling"	26	Nucleoplasm	"Nucleoli, Cytosol"	"CAB006853: , CAB015948: , HPA049074: , HPA054496: "	"unprognostic (1.37e-1)"	"unprognostic (1.66e-2)"	"unprognostic (4.59e-2)"	"unprognostic (3.83e-2)"	"unprognostic (7.79e-2)"	"unprognostic (2.33e-1)"	"unprognostic (6.84e-2)"	"unprognostic (2.47e-1)"	"unprognostic (2.10e-1)"	"unprognostic (5.14e-2)"	"potential prognostic unfavorable (2.18e-5)"	"unprognostic (7.92e-2)"	"unprognostic (4.22e-3)"	"unprognostic (7.13e-3)"	"unprognostic (1.28e-1)"	"unprognostic (1.06e-2)"	"unprognostic (2.19e-1)"	"unprognostic (1.22e-1)"	"unprognostic (1.13e-1)"	"unprognostic (9.80e-2)"	"unprognostic (3.86e-1)"	"unprognostic (2.41e-2)"	"unprognostic (4.84e-2)"	"unprognostic (1.02e-1)"	"unprognostic (3.71e-2)"	"unprognostic (1.98e-2)"	"unprognostic (3.19e-1)"	"unprognostic (9.02e-3)"	"unprognostic (1.84e-1)"	"unprognostic (1.92e-1)"	"unprognostic (5.89e-2)"
NLRP3	"AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1"	ENSG00000162711	"NLR family pyrin domain containing 3"		1	247416156-247449108	"Cancer-related genes, Human disease related genes, Predicted intracellular proteins"			"Cancer-related genes"	"Evidence at transcript level"	"Evidence at transcript level"			"Tissue enriched"	"Detected in many"	5	"bone marrow: 51.5"	"Cell type enhanced"	"Detected in some"		"cDC: 28.6;Macrophages: 48.1;Microglia: 66.5;Monocyte progenitors: 23.8;monocytes: 259.6;Neutrophils: 173.2"	"Cell type enriched"	"Detected in many"	6	"central nervous system macrophage: 82.8"	"Low cancer specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Immune cell enhanced"	"Detected in many"		"basophil: 129.9"	"Group enriched"	"Detected in many"	23	"dendritic cells: 37.3;granulocytes: 129.9;monocytes: 35.6"	"Cancer enriched"	"Detected in many"	6	"Leukemia: 11.8"	"Adrenal gland - Macrophages, Heart muscle - Macrophages, Minor Salivary Gland - Macrophages"	"Not detected"	"Not detected"			"Low region specificity"	"Detected in many"			HPA012878	Uncertain						NA	NA			"Cluster 46: Basophils - Proteolysis"	"Cluster 15: Bone marrow - Innate immune response"	"Cluster 20: Macrophages & Microglia - Immune response"	"Cluster 14: Myeloid leukemia - Innate immune response"	"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling"	28			"HPA012878: "		"unprognostic (1.36e-1)"	"unprognostic (6.46e-2)"			"unprognostic (5.48e-2)"	"unprognostic (1.18e-1)"	"unprognostic (1.50e-1)"	"unprognostic (2.22e-1)"		"unprognostic (1.91e-3)"	"unprognostic (3.73e-1)"	"unprognostic (4.95e-2)"			"unprognostic (2.12e-2)"	"unprognostic (2.70e-2)"		"unprognostic (4.78e-2)"		"unprognostic (7.09e-2)"	"unprognostic (1.30e-2)"	"unprognostic (1.61e-1)"			"unprognostic (1.06e-1)"		"unprognostic (5.48e-3)"		"unprognostic (6.44e-2)"