Skin cancer

The upper left dot plot(s) shows the consistency between the cancer type related cell lines and their corresponding TCGA disease cohort based on Spearman correlation and normalized enrichment score (NES). In the lower left is a list of the cell lines ranked according to their similarity to the cancer type. By clicking on a cell line in the dot plot or in the ranked list lollipop plots showing the activity of cancer-related pathways inferred using PROGENy and CytoSig cytokines for that particular cell line will be displayed. For more details about the analysis see Methods summary and information about all cell lines can be found here.

Skin Cutaneous Melanoma (SKCM)

Explore the disease cohort in TCGA

Malme-3MHs 939.TUACC-257SK-MEL-30HMY-1COLO 783HT-144SK-MEL-28G-361COLO 829WM1799COLO 794COLO 800Hs 294TK029AXRVH-421Hs 944.TSK-MEL-5SK-MEL-24Mel HoCOLO 792IGR-37SK-MEL-31WM266-4SK-MEL-3SH-4DEOC-1IPC-298MeWoC32 [Human melanoma]COLO 741UCSD-242LWM88A101DA2058IGR-1COLO 849COLO 679Hs 936.TWM983BWM115UACC-62SK-MEL-1SK-MEL-2Mel JuSo624-mel537-melHs 695THs 852.TMel 928RPMI-7951SK-MEL-23888-melWM793MDA-MB-435IGR-39A-375MDA-MB-435SHMCBA-431LOX-IMVICJM [Human melanoma]0.760.780.80.82Spearman's ฯ11.52NES
Ranking
Cell line
Corr
NES
1 Malme-3M 0.83 2.36
2 Hs 939.T 0.82 2.39
2 UACC-257 0.82 2.36
4 SK-MEL-30 0.82 2.26
5 HMY-1 0.81 2.3
6 COLO 783 0.81 2.33
6 HT-144 0.81 2.33
8 SK-MEL-28 0.81 2.25
9 G-361 0.81 2.27
10 COLO 829 0.82 2.22
11 WM1799 0.81 2.33
12 COLO 794 0.81 2.24
13 COLO 800 0.81 2.22
13 Hs 294T 0.81 2.27
15 K029AX 0.81 2.23
16 RVH-421 0.81 2.26
17 Hs 944.T 0.81 2.21
18 SK-MEL-5 0.8 2.33
19 SK-MEL-24 0.81 2.16
20 Mel Ho 0.81 2.15
20 COLO 792 0.81 2.18
22 IGR-37 0.8 2.25
22 SK-MEL-31 0.8 2.22
24 WM266-4 0.81 2.2
24 SK-MEL-3 0.8 2.25
24 SH-4 0.8 2.24
27 DEOC-1 0.81 2.2
27 IPC-298 0.8 2.21
29 MeWo 0.8 2.2
30 C32 [Human melanoma] 0.81 2.15
30 COLO 741 0.8 2.23
32 UCSD-242L 0.8 2.21
33 WM88 0.81 2.09
33 A101D 0.8 2.17
35 A2058 0.81 2.15
36 IGR-1 0.8 2.21
37 COLO 849 0.8 2.14
38 COLO 679 0.8 2.18
39 Hs 936.T 0.8 2.2
40 WM983B 0.8 2.09
41 WM115 0.79 2.17
41 UACC-62 0.8 2.16
43 SK-MEL-1 0.8 2.08
44 SK-MEL-2 0.79 2.14
44 Mel JuSo 0.79 2.04
44 624-mel 0.79 2.02
47 537-mel 0.8 1.88
48 Hs 695T 0.79 2.01
49 Hs 852.T 0.79 1.96
50 Mel 928 0.79 1.89
51 RPMI-7951 0.79 1.61
52 SK-MEL-23 0.78 2
52 888-mel 0.78 1.93
54 WM793 0.79 1.77
55 MDA-MB-435 0.78 1.75
56 IGR-39 0.78 1.67
57 A-375 0.78 1.7
57 MDA-MB-435S 0.77 1.76
59 HMCB 0.76 1.69
60 A-431 0.77 0.85
61 LOX-IMVI 0.75 1.17
62 CJM [Human melanoma] 0.75 0.8
CELL LINE DATA
Cell line Malme-3M
Patient: Male, 43
Disease subtype: Melanoma
Primary/metastasis: Metastasis
Sample collection site: Lung
Cellosaurus: CVCL_1438
PROGENy
AndrogenEGFREstrogenHypoxiaJAK-STATMAPKNFkBp53PI3KTGFbTNFaTrailVEGFWNTNES-1.5-1.0-0.50.00.51.01.52.0Z-scoreSignificant - upregulatedSignificant - downregulatedNon significant
CytoSig
Activin ABDNFBMP2BMP4BMP6CD40LCXCL12EGFFGF2GCSFGDF11GMCSFHGFIFN1IFNGIFNLIL10IL12IL13IL15IL17AIL1AIL1BIL2IL21IL22IL27IL3IL36IL4IL6LIFLTAMCSFNOOSMTGFB1TGFB3TNFATRAILTWEAKVEGFAWNT3ANES-5051015Z-score