Head and neck cancer

The upper left dot plot(s) shows the consistency between the cancer type related cell lines and their corresponding TCGA disease cohort based on Spearman correlation and normalized enrichment score (NES). In the lower left is a list of the cell lines ranked according to their similarity to the cancer type. By clicking on a cell line in the dot plot or in the ranked list lollipop plots showing the activity of cancer-related pathways inferred using PROGENy and CytoSig cytokines for that particular cell line will be displayed. For more details about the analysis see Methods summary and information about all cell lines can be found here.

Head and Neck Squamous Cell Carcinoma (HNSC)

Explore the disease cohort in TCGA

SCC-15BICR 16BICR 31BICR 22SCC-25PE/CA-PJ34 (clone C12)SNU-1214BICR 6SCC-9BICR 56BICR 78DOKSCC-4CAL-27A-253PE/CA-PJ49YD-10BBHYPE/CA-PJ15PE/CA-PJ41 (clone D2)SNU-1041SNU-899HSC-2CAL-33HSC-4YD-38SNU-1076Detroit 562BICR 18SNU-1066HNYD-15HSC-3FaDuBICR 10YD-8SNU-46RPMI-26500.70.750.8Spearman's ฯ11.52NES
Ranking
Cell line
Corr
NES
1 SCC-15 0.82 2.43
2 BICR 16 0.81 2.43
3 BICR 31 0.81 2.32
4 BICR 22 0.81 2.24
4 SCC-25 0.81 2.22
6 PE/CA-PJ34 (clone C1 0.82 2.18
6 SNU-1214 0.81 2.39
8 BICR 6 0.81 2.27
9 SCC-9 0.8 2.48
10 BICR 56 0.81 2.19
11 BICR 78 0.8 2.4
12 DOK 0.81 2.09
13 SCC-4 0.8 2.11
14 CAL-27 0.8 2.07
15 A-253 0.8 2.18
16 PE/CA-PJ49 0.8 1.83
17 YD-10B 0.8 2
18 BHY 0.79 2.06
19 PE/CA-PJ15 0.8 1.83
19 PE/CA-PJ41 (clone D2 0.8 1.89
19 SNU-1041 0.8 1.83
22 SNU-899 0.79 1.91
23 HSC-2 0.79 1.99
24 CAL-33 0.79 1.87
25 HSC-4 0.79 1.97
26 YD-38 0.79 1.67
27 SNU-1076 0.78 1.73
27 Detroit 562 0.79 1.51
29 BICR 18 0.77 1.77
30 SNU-1066 0.78 1.64
31 HN 0.77 1.66
32 YD-15 0.78 1.49
33 HSC-3 0.77 1.64
34 FaDu 0.77 1.45
35 BICR 10 0.76 1.39
36 YD-8 0.77 0.95
37 SNU-46 0.75 1.04
37 RPMI-2650 0.69 1.26
CELL LINE DATA
Cell line SCC-15
Patient: Male, 55
Disease subtype: Squamous Cell Carcinoma
Primary/metastasis:
Sample collection site: Upper aerodigestive tract
Cellosaurus: CVCL_1681
PROGENy
AndrogenEGFREstrogenHypoxiaJAK-STATMAPKNFkBp53PI3KTGFbTNFaTrailVEGFWNTNES-1.0-0.50.00.51.01.52.02.5Z-scoreSignificant - upregulatedSignificant - downregulatedNon significant
CytoSig
Activin ABDNFBMP2BMP4BMP6CD40LCXCL12EGFFGF2GCSFGDF11GMCSFHGFIFN1IFNGIFNLIL10IL12IL13IL15IL17AIL1AIL1BIL2IL21IL22IL27IL3IL36IL4IL6LIFLTAMCSFNOOSMTGFB1TGFB3TNFATRAILTWEAKVEGFAWNT3ANES-5051015Z-score