Colorectal cancer

The upper left dot plot(s) shows the consistency between the cancer type related cell lines and their corresponding TCGA disease cohort based on Spearman correlation and normalized enrichment score (NES). In the lower left is a list of the cell lines ranked according to their similarity to the cancer type. By clicking on a cell line in the dot plot or in the ranked list lollipop plots showing the activity of cancer-related pathways inferred using PROGENy and CytoSig cytokines for that particular cell line will be displayed. For more details about the analysis see Methods summary and information about all cell lines can be found here.

Colon Adenocarcinoma (COAD)

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SW1116HCC-56CL-34SW1463SNU-C4NCI-H684CL-14NCI-H508HT115SNU-283HT-55SW403LS180LS1034HCC1263CL-40SNU-61T84SW948LS513SNU-C1RCM-1 [Human rectal adenocarcinoma]CW-2GP2dCCK-81SNU-1040SK-CO-1SNU-1033SNU-81LS411NLoVoSW1417HT-29SNU-407COLO 201C170COLO 206FCL-11SNU-1197SW837SNU-175KM12CACO-2C2BBe1LS123HCA7SNU-C5SW48NCI-H747SW620NCI-H716SW480OUMS-23HCT 15COLO 678CaR-1SNU-C2ACOLO 320RKOCOLO 320DMSNU-503HCT 116MDST80.720.740.760.780.80.82Spearman's ฯ11.52NES
Ranking
Cell line
Corr
NES
1 SW1116 0.83 2.24
1 HCC-56 0.83 2.34
3 CL-34 0.82 2.32
4 SW1463 0.83 2.19
5 SNU-C4 0.82 2.27
6 NCI-H684 0.83 2.19
7 CL-14 0.82 2.23
8 NCI-H508 0.82 2.25
8 HT115 0.82 2.2
8 SNU-283 0.83 2.17
11 HT-55 0.82 2.22
12 SW403 0.83 2.14
13 LS180 0.81 2.25
14 LS1034 0.82 2.23
15 HCC1263 0.83 2.14
16 CL-40 0.83 2.11
17 SNU-61 0.82 2.14
18 T84 0.82 2.18
19 SW948 0.82 2.13
19 LS513 0.81 2.2
21 SNU-C1 0.81 2.15
22 RCM-1 [Human rectal 0.81 2.16
22 CW-2 0.82 2.14
24 GP2d 0.8 2.19
25 CCK-81 0.8 2.16
26 SNU-1040 0.81 1.98
26 SK-CO-1 0.81 2.02
28 SNU-1033 0.81 1.99
29 SNU-81 0.81 2.02
30 LS411N 0.81 1.88
31 LoVo 0.81 1.94
32 SW1417 0.8 1.89
33 HT-29 0.8 1.75
34 SNU-407 0.79 1.97
35 COLO 201 0.79 1.88
36 C170 0.8 1.76
37 COLO 206F 0.79 1.83
38 CL-11 0.79 1.71
39 SNU-1197 0.8 1.62
39 SW837 0.8 1.5
41 SNU-175 0.78 1.9
41 KM12 0.79 1.73
43 CACO-2 0.79 1.66
44 C2BBe1 0.78 1.74
45 LS123 0.79 1.51
46 HCA7 0.79 1.38
47 SNU-C5 0.79 1.44
48 SW48 0.79 1.36
49 NCI-H747 0.78 1.39
50 SW620 0.77 1.56
51 NCI-H716 0.74 1.68
52 SW480 0.77 1.35
53 OUMS-23 0.75 1.41
53 HCT 15 0.78 1.23
53 COLO 678 0.78 1.15
56 CaR-1 0.77 1
57 SNU-C2A 0.77 0.93
58 COLO 320 0.72 1.33
59 RKO 0.74 1.09
59 COLO 320DM 0.72 1.29
61 SNU-503 0.75 0.89
61 HCT 116 0.76 0.64
63 MDST8 0.73 0.65
CELL LINE DATA
Cell line SW1116
Patient: Male, 73
Disease subtype: Adenocarcinoma
Primary/metastasis: Primary
Sample collection site: Colon
Cellosaurus: CVCL_0544
PROGENy
AndrogenEGFREstrogenHypoxiaJAK-STATMAPKNFkBp53PI3KTGFbTNFaTrailVEGFWNTNES-2-10123Z-scoreSignificant - upregulatedSignificant - downregulatedNon significant
CytoSig
Activin ABDNFBMP2BMP4BMP6CD40LCXCL12EGFFGF2GCSFGDF11GMCSFHGFIFN1IFNGIFNLIL10IL12IL13IL15IL17AIL1AIL1BIL2IL21IL22IL27IL3IL36IL4IL6LIFLTAMCSFNOOSMTGFB1TGFB3TNFATRAILTWEAKVEGFAWNT3ANES-6-4-202468Z-score

Rectum Adenocarcinoma (READ)

Explore the disease cohort in TCGA

SW1116HCC-56CL-34CL-14HT-55SW1463SNU-283SW403NCI-H684HT115NCI-H508LS1034SNU-C4SNU-C1RCM-1 [Human rectal adenocarcinoma]SNU-61HCC1263T84SW948LS180CL-40CW-2LS513SNU-1033SNU-1040SK-CO-1GP2dSNU-81SW1417CCK-81LS411NLoVoHT-29COLO 201SNU-407CL-11COLO 206FC170SW837SNU-1197CACO-2C2BBe1KM12SNU-175SW48HCA7LS123SW620COLO 678SNU-C5OUMS-23NCI-H716NCI-H747SW480HCT 15COLO 320DMCOLO 320CaR-1SNU-C2ASNU-503HCT 116RKOMDST80.740.760.780.80.82Spearman's ฯ11.52NES
Ranking
Cell line
Corr
NES
1 SW1116 0.83 2.33
1 HCC-56 0.83 2.4
3 CL-34 0.82 2.38
4 CL-14 0.83 2.31
5 HT-55 0.82 2.31
6 SW1463 0.84 2.24
7 SNU-283 0.83 2.24
8 SW403 0.84 2.21
8 NCI-H684 0.83 2.23
10 HT115 0.82 2.28
10 NCI-H508 0.82 2.3
12 LS1034 0.82 2.31
13 SNU-C4 0.82 2.26
14 SNU-C1 0.82 2.26
14 RCM-1 [Human rectal 0.82 2.29
16 SNU-61 0.82 2.22
16 HCC1263 0.83 2.19
16 T84 0.82 2.25
19 SW948 0.82 2.22
20 LS180 0.81 2.26
21 CL-40 0.83 2.14
22 CW-2 0.82 2.19
22 LS513 0.81 2.24
24 SNU-1033 0.81 2.17
25 SNU-1040 0.81 2.1
26 SK-CO-1 0.81 2.12
27 GP2d 0.8 2.21
28 SNU-81 0.81 2.04
28 SW1417 0.81 2.07
30 CCK-81 0.8 2.15
31 LS411N 0.81 1.92
32 LoVo 0.81 2.03
33 HT-29 0.8 1.88
34 COLO 201 0.79 2.01
35 SNU-407 0.79 2.02
36 CL-11 0.79 1.9
36 COLO 206F 0.79 1.97
38 C170 0.79 1.82
39 SW837 0.8 1.61
39 SNU-1197 0.8 1.76
41 CACO-2 0.79 1.81
42 C2BBe1 0.78 1.89
43 KM12 0.79 1.68
43 SNU-175 0.78 1.87
45 SW48 0.79 1.52
46 HCA7 0.79 1.39
46 LS123 0.79 1.42
48 SW620 0.77 1.79
49 COLO 678 0.78 1.42
50 SNU-C5 0.78 1.38
50 OUMS-23 0.76 1.68
52 NCI-H716 0.74 1.73
53 NCI-H747 0.78 1.38
54 SW480 0.78 1.4
55 HCT 15 0.78 1.36
56 COLO 320DM 0.72 1.59
56 COLO 320 0.72 1.54
58 CaR-1 0.77 1.26
59 SNU-C2A 0.77 1.05
60 SNU-503 0.75 1.3
61 HCT 116 0.76 0.83
62 RKO 0.74 0.96
62 MDST8 0.73 0.97
CELL LINE DATA
Cell line SW1116
Patient: Male, 73
Disease subtype: Adenocarcinoma
Primary/metastasis: Primary
Sample collection site: Colon
Cellosaurus: CVCL_0544
PROGENy
AndrogenEGFREstrogenHypoxiaJAK-STATMAPKNFkBp53PI3KTGFbTNFaTrailVEGFWNTNES-2-10123Z-scoreSignificant - upregulatedSignificant - downregulatedNon significant
CytoSig
Activin ABDNFBMP2BMP4BMP6CD40LCXCL12EGFFGF2GCSFGDF11GMCSFHGFIFN1IFNGIFNLIL10IL12IL13IL15IL17AIL1AIL1BIL2IL21IL22IL27IL3IL36IL4IL6LIFLTAMCSFNOOSMTGFB1TGFB3TNFATRAILTWEAKVEGFAWNT3ANES-6-4-202468Z-score