Cell line - ENSG00000288520 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENSG00000288520
Gene descriptionⁱ Full gene name according to HGNC.	Novel protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression based on cell line data from the DepMap portal and cell line data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Thyroid cancer - Neuronal signaling (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Not detected
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	Not detected
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Not detected
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

CELL LINE GROUPSⁱ

Cell line categories

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RNA specificity: Not detected

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COMMON CELL LINESⁱ

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EXPRESSION CLUSTERING & CORRELATIONⁱ

ENSG00000288520 is part of cluster 16 Thyroid cancer - Neuronal signaling with confidenceⁱ 1
242 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MT1HL1	Metallothionein 1H like 1	0.6297	16
NTMT2	N-terminal Xaa-Pro-Lys N-methyltransferase 2	0.6290	16
UCN3	Urocortin 3	0.6083	16
BAALC	BAALC binder of MAP3K1 and KLF4	0.6052	16
HOXB5	Homeobox B5	0.5976	16
VWA5A	Von Willebrand factor A domain containing 5A	0.5958	16
NPHS2	NPHS2 stomatin family member, podocin	0.5933	16
FGF19	Fibroblast growth factor 19	0.5689	16
CSMD3	CUB and Sushi multiple domains 3	0.5645	16
CD300LG	CD300 molecule like family member g	0.5621	16
SLC5A7	Solute carrier family 5 member 7	0.5611	16
VN1R5	Vomeronasal 1 receptor 5 (gene/pseudogene)	0.5567	16
CBLN2	Cerebellin 2 precursor	0.5544	16
OR8G5	Olfactory receptor family 8 subfamily G member 5	0.5503	16
MAB21L4	Mab-21 like 4	0.5319	16

CELL LINE DATA

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Adrenocortical cancer (n=1)

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Bile duct cancer (n=7)

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Bladder cancer (n=26)

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Bone cancer (n=21)

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Brain cancer (n=80)

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Breast cancer (n=62)

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Cervical cancer (n=8)

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Colorectal cancer (n=63)

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Esophageal cancer (n=27)

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Gallbladder cancer (n=1)

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Gastric cancer (n=42)

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Head and Neck cancer (n=38)

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Kidney cancer (n=35)

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Leukemia (n=93)

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Liver cancer (n=24)

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Lung cancer (n=232)

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Lymphoma (n=76)

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Myeloma (n=34)

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Neuroblastoma (n=17)

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Non-cancerous (n=63)

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Ovarian cancer (n=59)

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Pancreatic cancer (n=46)

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Prostate cancer (n=8)

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Rhabdoid (n=14)

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Sarcoma (n=15)

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Skin cancer (n=62)

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Testis cancer (n=1)

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Thyroid cancer (n=11)

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Uncategorized (n=11)

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Uterine cancer (n=29)

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