Single cell type - HAAO - The Human Protein Atlas

HAAO

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HAAO
Gene descriptionⁱ Full gene name according to HGNC.	3-hydroxyanthranilate 3,4-dioxygenase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Hepatocytes - Metabolism (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Proximal enterocytes, Hepatocytes, Proximal tubular cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.73
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Central nervous system macrophage)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (myeloid DC)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Proximal enterocytes, Hepatocytes, Proximal tubular cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Central nervous system macrophage)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (myeloid DC)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

HAAO is part of cluster 43 Hepatocytes - Metabolism with confidenceⁱ 1
200 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FUOM	Fucose mutarotase	0.8454	43
GLYCTK	Glycerate kinase	0.7783	43
TTC36	Tetratricopeptide repeat domain 36	0.7684	43
PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial	0.7517	22
GSTA1	Glutathione S-transferase alpha 1	0.7511	22
G6PC1	Glucose-6-phosphatase catalytic subunit 1	0.7192	43
ACOX2	Acyl-CoA oxidase 2	0.7191	43
TMEM256	Transmembrane protein 256	0.7187	22
SMLR1	Small leucine rich protein 1	0.6965	43
DHRS4L2	Dehydrogenase/reductase 4 like 2	0.6950	22
TKFC	Triokinase and FMN cyclase	0.6904	22
KDM8	Lysine demethylase 8	0.6884	43
PXMP2	Peroxisomal membrane protein 2	0.6824	43
PCK1	Phosphoenolpyruvate carboxykinase 1	0.6740	56
OXER1	Oxoeicosanoid receptor 1	0.6729	22

IMMUNE CELLS

HAAO is part of cluster 29 Non-specific - Unknown function with confidenceⁱ 0.98
401 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ATP5ME	ATP synthase membrane subunit e	1.0000	29
TIMM17B	Translocase of inner mitochondrial membrane 17B	1.0000	29
GAPT	GRB2 binding adaptor protein, transmembrane	0.9762	29
SCAND1	SCAN domain containing 1	0.9762	29
CUEDC2	CUE domain containing 2	0.9762	29
PRDX5	Peroxiredoxin 5	0.9762	29
TMEM219	Transmembrane protein 219	0.9762	29
TMEM138	Transmembrane protein 138	0.9762	29
SERF2	Small EDRK-rich factor 2	0.9524	29
MZT2B	Mitotic spindle organizing protein 2B	0.9524	29
NDUFC2	NADH:ubiquinone oxidoreductase subunit C2	0.9524	22
TIMM8B	Translocase of inner mitochondrial membrane 8 homolog B	0.9524	29
SLC47A1	Solute carrier family 47 member 1	0.9524	29
BAD	BCL2 associated agonist of cell death	0.9524	29
NDUFA2	NADH:ubiquinone oxidoreductase subunit A2	0.9524	29

Adipocytes	2.2 nTPM
Breast	3.6 nTPM
Adipose tissue	0.8 nTPM

Alveolar cells type 1	0.2 nTPM
Lung	0.2 nTPM

Alveolar cells type 2	0.4 nTPM
Lung	0.4 nTPM

Astrocytes	3.4 nTPM
Brain	3.4 nTPM

B-cells	3.8 nTPM
Kidney	10.4 nTPM
Liver	9.7 nTPM
Skin	6.8 nTPM
Esophagus	5.9 nTPM
Bone marrow	4.1 nTPM
Lymph node	2.9 nTPM
Stomach	2.5 nTPM
Thymus	2.2 nTPM
Spleen	2.1 nTPM
Lung	1.3 nTPM
Salivary gland	1.0 nTPM
Adipose tissue	0.8 nTPM
PBMC	0.0 nTPM

Ciliated cells	0.7 nTPM
Bronchus	1.0 nTPM
Fallopian tube	0.9 nTPM
Lung	0.5 nTPM
Endometrium	0.3 nTPM

Club cells	1.6 nTPM
Bronchus	2.6 nTPM
Lung	1.4 nTPM
Prostate	0.9 nTPM

Endothelial cells	0.9 nTPM
Ovary	4.3 nTPM
Skeletal muscle	1.7 nTPM
Heart muscle	1.6 nTPM
Tongue	1.5 nTPM
Liver	1.3 nTPM
Vascular	1.3 nTPM
Endometrium	1.0 nTPM
Prostate	1.0 nTPM
Fallopian tube	0.7 nTPM
Testis	0.6 nTPM
Placenta	0.6 nTPM
Skin	0.6 nTPM
Lung	0.4 nTPM
Thymus	0.3 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Salivary gland	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	13.3 nTPM
Small intestine	27.5 nTPM
Colon	7.3 nTPM
Rectum	5.0 nTPM

Fibroblasts	13.6 nTPM
Stomach	43.2 nTPM
Esophagus	33.2 nTPM
Fallopian tube	19.5 nTPM
Placenta	17.8 nTPM
Breast	15.6 nTPM
Prostate	12.5 nTPM
Adipose tissue	10.7 nTPM
Heart muscle	10.5 nTPM
Salivary gland	9.6 nTPM
Skin	9.0 nTPM
Thymus	8.9 nTPM
Vascular	8.7 nTPM
Skeletal muscle	8.2 nTPM
Liver	4.7 nTPM
Pancreas	3.3 nTPM
Lung	2.3 nTPM

Granulocytes	15.6 nTPM
Lung	18.7 nTPM
Fallopian tube	18.6 nTPM
Tongue	9.7 nTPM

Intestinal goblet cells	13.7 nTPM
Small intestine	31.5 nTPM
Rectum	6.0 nTPM
Colon	3.7 nTPM

Lymphatic endothelial cells	3.5 nTPM
Ovary	5.5 nTPM
Fallopian tube	1.5 nTPM

Macrophages	7.0 nTPM
Kidney	21.2 nTPM
Fallopian tube	11.6 nTPM
Bone marrow	11.1 nTPM
Breast	9.4 nTPM
Adipose tissue	9.3 nTPM
Pancreas	8.2 nTPM
Prostate	7.9 nTPM
Skin	7.8 nTPM
Skeletal muscle	7.8 nTPM
Esophagus	6.4 nTPM
Endometrium	5.5 nTPM
Testis	5.0 nTPM
Spleen	5.0 nTPM
Vascular	3.4 nTPM
Tongue	3.0 nTPM
Salivary gland	2.9 nTPM
Thymus	2.7 nTPM
Stomach	2.6 nTPM
Lung	2.6 nTPM

Paneth cells	35.5 nTPM
Small intestine	44.9 nTPM
Colon	43.4 nTPM
Rectum	18.2 nTPM

Basal keratinocytes	3.1 nTPM
Skin	3.1 nTPM
Tongue	3.1 nTPM

Basal prostatic cells	1.9 nTPM
Prostate	1.9 nTPM

Basal squamous epithelial cells	10.0 nTPM
Esophagus	10.0 nTPM

Cholangiocytes	19.1 nTPM
Liver	19.1 nTPM

Plasma cells	1.2 nTPM
Fallopian tube	5.1 nTPM
Bone marrow	1.5 nTPM
Liver	1.0 nTPM
Thymus	1.0 nTPM
Stomach	0.4 nTPM
Salivary gland	0.4 nTPM
Spleen	0.2 nTPM
Esophagus	0.0 nTPM

Schwann cells	1.3 nTPM
Vascular	3.7 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.6 nTPM
Salivary gland	1.2 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	16.4 nTPM
Placenta	45.2 nTPM
Esophagus	31.2 nTPM
Ovary	25.5 nTPM
Prostate	19.5 nTPM
Breast	18.2 nTPM
Adipose tissue	17.6 nTPM
Skeletal muscle	16.9 nTPM
Vascular	14.9 nTPM
Fallopian tube	12.8 nTPM
Thymus	11.9 nTPM
Endometrium	11.1 nTPM
Skin	10.4 nTPM
Tongue	9.6 nTPM
Lung	8.2 nTPM
Salivary gland	6.8 nTPM
Liver	3.4 nTPM

T-cells	0.9 nTPM
Liver	6.0 nTPM
Colon	4.9 nTPM
Kidney	2.7 nTPM
Vascular	1.2 nTPM
Endometrium	0.8 nTPM
Skin	0.7 nTPM
Prostate	0.6 nTPM
PBMC	0.4 nTPM
Skeletal muscle	0.4 nTPM
Tongue	0.4 nTPM
Breast	0.3 nTPM
Lymph node	0.2 nTPM
Salivary gland	0.2 nTPM
Stomach	0.1 nTPM
Thymus	0.1 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Lung	0.0 nTPM
Fallopian tube	0.0 nTPM

Undifferentiated cells	23.8 nTPM
Small intestine	50.2 nTPM
Rectum	11.2 nTPM
Colon	10.0 nTPM

Amygdala excitatory	5.9 nTPM
Cerebral cortex	8.8 nTPM
Hippocampus	7.7 nTPM
Basal ganglia	6.8 nTPM
Amygdala	5.5 nTPM
Thalamus	4.5 nTPM
Hypothalamus	2.1 nTPM

Astrocyte	11.1 nTPM
Cerebellum	17.1 nTPM
Medulla oblongata	13.7 nTPM
Hypothalamus	13.5 nTPM
Midbrain	13.3 nTPM
Basal ganglia	13.2 nTPM
Spinal cord	11.9 nTPM
Pons	10.6 nTPM
Thalamus	9.4 nTPM
Amygdala	7.4 nTPM
Cerebral cortex	5.9 nTPM
Hippocampus	5.6 nTPM

Bergmann glia	9.6 nTPM
Medulla oblongata	17.0 nTPM
Cerebellum	8.7 nTPM
Pons	2.9 nTPM

Central nervous system macrophage	49.4 nTPM
Cerebral cortex	55.8 nTPM
Basal ganglia	54.2 nTPM
Amygdala	53.9 nTPM
Hypothalamus	52.0 nTPM
Hippocampus	50.7 nTPM
Midbrain	48.4 nTPM
Pons	47.6 nTPM
Medulla oblongata	47.2 nTPM
Thalamus	46.1 nTPM
Cerebellum	44.6 nTPM
Spinal cord	43.0 nTPM

Cerebellar inhibitory	2.7 nTPM
Cerebellum	4.2 nTPM
Medulla oblongata	3.7 nTPM
Pons	3.0 nTPM
Midbrain	2.5 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	4.6 nTPM
Midbrain	6.3 nTPM
Basal ganglia	5.3 nTPM
Thalamus	5.1 nTPM
Cerebral cortex	4.8 nTPM
Hippocampus	4.5 nTPM
Amygdala	4.0 nTPM
Hypothalamus	2.0 nTPM

Choroid plexus epithelial cell	18.5 nTPM
Basal ganglia	23.4 nTPM
Medulla oblongata	23.1 nTPM
Hippocampus	22.2 nTPM
Thalamus	5.5 nTPM

Committed oligodendrocyte precursor	2.3 nTPM
Basal ganglia	6.0 nTPM
Cerebral cortex	3.8 nTPM
Hippocampus	3.6 nTPM
Pons	2.7 nTPM
Medulla oblongata	2.6 nTPM
Midbrain	2.5 nTPM
Cerebellum	1.6 nTPM
Thalamus	0.9 nTPM
Hypothalamus	0.7 nTPM
Amygdala	0.6 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	4.8 nTPM
Cerebral cortex	6.8 nTPM
Basal ganglia	5.8 nTPM
Hippocampus	5.6 nTPM
Amygdala	4.6 nTPM
Midbrain	4.4 nTPM
Hypothalamus	1.8 nTPM

Deep-layer intratelencephalic	6.7 nTPM
Basal ganglia	8.7 nTPM
Hippocampus	8.1 nTPM
Cerebral cortex	7.4 nTPM
Amygdala	6.7 nTPM
Hypothalamus	2.5 nTPM

Deep-layer near-projecting	6.3 nTPM
Hippocampus	10.7 nTPM
Basal ganglia	8.5 nTPM
Cerebral cortex	6.8 nTPM
Amygdala	3.2 nTPM
Hypothalamus	2.4 nTPM

Eccentric medium spiny neuron	3.7 nTPM
Hippocampus	5.0 nTPM
Cerebral cortex	4.3 nTPM
Basal ganglia	4.0 nTPM
Amygdala	3.5 nTPM
Thalamus	3.3 nTPM
Hypothalamus	2.1 nTPM

Endothelial cell	2.4 nTPM
Thalamus	5.6 nTPM
Cerebral cortex	5.1 nTPM
Basal ganglia	3.7 nTPM
Spinal cord	3.5 nTPM
Medulla oblongata	3.1 nTPM
Hippocampus	2.2 nTPM
Hypothalamus	1.2 nTPM
Pons	1.2 nTPM
Cerebellum	0.8 nTPM
Amygdala	0.0 nTPM
Midbrain	0.0 nTPM

Ependymal cell	14.7 nTPM
Amygdala	19.9 nTPM
Hypothalamus	17.8 nTPM
Midbrain	17.8 nTPM
Hippocampus	17.5 nTPM
Basal ganglia	15.7 nTPM
Pons	13.7 nTPM
Thalamus	13.0 nTPM
Medulla oblongata	12.7 nTPM
Spinal cord	3.8 nTPM