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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q35
Chromosome location (bp)
219195237 - 219209651
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway 1....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q8WV99 [Direct mapping] AN1-type zinc finger protein 2B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000502[proteasome complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0006616[SRP-dependent cotranslational protein targeting to membrane, translocation] GO:0008270[zinc ion binding] GO:0016020[membrane] GO:0031593[polyubiquitin modification-dependent protein binding] GO:0036435[K48-linked polyubiquitin modification-dependent protein binding] GO:0043130[ubiquitin binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043567[regulation of insulin-like growth factor receptor signaling pathway] GO:0045047[protein targeting to ER] GO:0046872[metal ion binding]
Q8WV99 [Direct mapping] AN1-type zinc finger protein 2B
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502[proteasome complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0006616[SRP-dependent cotranslational protein targeting to membrane, translocation] GO:0008270[zinc ion binding] GO:0016020[membrane] GO:0036435[K48-linked polyubiquitin modification-dependent protein binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043567[regulation of insulin-like growth factor receptor signaling pathway] GO:0045047[protein targeting to ER] GO:0046872[metal ion binding]
Q8WV99 [Direct mapping] AN1-type zinc finger protein 2B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502[proteasome complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0006616[SRP-dependent cotranslational protein targeting to membrane, translocation] GO:0008270[zinc ion binding] GO:0016020[membrane] GO:0036435[K48-linked polyubiquitin modification-dependent protein binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043567[regulation of insulin-like growth factor receptor signaling pathway] GO:0045047[protein targeting to ER] GO:0046872[metal ion binding]
Q8WV99 [Direct mapping] AN1-type zinc finger protein 2B
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502[proteasome complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0006616[SRP-dependent cotranslational protein targeting to membrane, translocation] GO:0008270[zinc ion binding] GO:0016020[membrane] GO:0036435[K48-linked polyubiquitin modification-dependent protein binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043567[regulation of insulin-like growth factor receptor signaling pathway] GO:0045047[protein targeting to ER] GO:0046872[metal ion binding]
Q8WV99 [Direct mapping] AN1-type zinc finger protein 2B
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502[proteasome complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0006616[SRP-dependent cotranslational protein targeting to membrane, translocation] GO:0008270[zinc ion binding] GO:0016020[membrane] GO:0036435[K48-linked polyubiquitin modification-dependent protein binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043567[regulation of insulin-like growth factor receptor signaling pathway] GO:0045047[protein targeting to ER] GO:0046872[metal ion binding]
The Human Protein Atlas project is funded
