Single cell type - HNRNPD - The Human Protein Atlas

HNRNPD

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HNRNPD
Gene descriptionⁱ Full gene name according to HGNC.	Heterogeneous nuclear ribonucleoprotein D
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.18
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

HNRNPD is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
835 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HNRNPR	Heterogeneous nuclear ribonucleoprotein R	0.6610	39
GRWD1	Glutamate rich WD repeat containing 1	0.6175	39
MCM3	Minichromosome maintenance complex component 3	0.5994	52
XRCC5	X-ray repair cross complementing 5	0.5796	39
NOP14	NOP14 nucleolar protein	0.5743	39
PAICS	Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	0.5735	39
PNO1	Partner of NOB1 homolog	0.5598	39
NOLC1	Nucleolar and coiled-body phosphoprotein 1	0.5597	39
MSH6	MutS homolog 6	0.5592	52
BMS1	BMS1 ribosome biogenesis factor	0.5546	39
EXOSC2	Exosome component 2	0.5474	39
GPATCH4	G-patch domain containing 4 (gene/pseudogene)	0.5443	39
THRAP3	Thyroid hormone receptor associated protein 3	0.5435	39
RPL7L1	Ribosomal protein L7 like 1	0.5425	39
SUPT16H	SPT16 homolog, facilitates chromatin remodeling subunit	0.5401	39

IMMUNE CELLS

HNRNPD is part of cluster 30 Non-specific - DNA binding with confidenceⁱ 0.95
263 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMOD4	Tropomodulin 4	1.0000	30
TIGD6	Tigger transposable element derived 6	0.9762	30
TMEM276	Transmembrane protein 276	0.9762	30
SDHAF3	Succinate dehydrogenase complex assembly factor 3	0.9762	30
WDR5	WD repeat domain 5	0.9762	30
TMEM86B	Transmembrane protein 86B	0.9762	13
PHLDB3	Pleckstrin homology like domain family B member 3	0.9762	13
ZNF621	Zinc finger protein 621	0.9762	30
TBC1D24	TBC1 domain family member 24	0.9762	30
SC5D	Sterol-C5-desaturase	0.9762	30
C1QBP	Complement C1q binding protein	0.9762	13
RPLP0	Ribosomal protein lateral stalk subunit P0	0.9762	30
NME1-NME2	NME1-NME2 readthrough	0.9524	13
SNUPN	Snurportin 1	0.9524	30
CHD3	Chromodomain helicase DNA binding protein 3	0.9524	30

Adipocytes	151.7 nTPM
Adipose tissue	172.2 nTPM
Breast	131.3 nTPM

Alveolar cells type 1	185.9 nTPM
Lung	185.9 nTPM

Alveolar cells type 2	239.4 nTPM
Lung	239.4 nTPM

Astrocytes	60.4 nTPM
Brain	60.4 nTPM

B-cells	140.2 nTPM
Salivary gland	254.6 nTPM
Thymus	207.5 nTPM
Lung	206.6 nTPM
Skin	179.6 nTPM
Adipose tissue	165.0 nTPM
PBMC	121.6 nTPM
Esophagus	118.0 nTPM
Lymph node	111.7 nTPM
Spleen	105.5 nTPM
Kidney	93.6 nTPM
Stomach	89.8 nTPM
Liver	86.9 nTPM
Bone marrow	82.0 nTPM

Basal squamous epithelial cells	120.8 nTPM
Esophagus	120.8 nTPM

Ciliated cells	125.3 nTPM
Fallopian tube	151.9 nTPM
Endometrium	133.9 nTPM
Lung	129.7 nTPM
Bronchus	85.8 nTPM

Club cells	140.6 nTPM
Lung	172.9 nTPM
Prostate	150.4 nTPM
Bronchus	98.6 nTPM

Dendritic cells	188.8 nTPM
Adipose tissue	241.0 nTPM
PBMC	136.7 nTPM

Endothelial cells	153.0 nTPM
Fallopian tube	274.0 nTPM
Lung	220.9 nTPM
Pancreas	191.3 nTPM
Skin	184.1 nTPM
Endometrium	182.2 nTPM
Thymus	168.8 nTPM
Salivary gland	156.1 nTPM
Skeletal muscle	145.7 nTPM
Ovary	144.8 nTPM
Placenta	138.0 nTPM
Breast	135.3 nTPM
Vascular	133.9 nTPM
Tongue	133.4 nTPM
Heart muscle	128.5 nTPM
Testis	112.6 nTPM
Prostate	105.4 nTPM
Liver	100.8 nTPM
Esophagus	98.7 nTPM

Enteroendocrine cells	112.8 nTPM
Colon	118.1 nTPM
Rectum	117.4 nTPM
Small intestine	103.0 nTPM

Erythroid cells	170.7 nTPM
Bone marrow	215.5 nTPM
Liver	125.9 nTPM

Fibroblasts	137.4 nTPM
Fallopian tube	210.3 nTPM
Placenta	202.5 nTPM
Lung	197.1 nTPM
Pancreas	185.2 nTPM
Adipose tissue	164.8 nTPM
Salivary gland	148.6 nTPM
Skeletal muscle	135.6 nTPM
Thymus	131.2 nTPM
Liver	126.9 nTPM
Vascular	112.7 nTPM
Skin	112.2 nTPM
Prostate	109.6 nTPM
Breast	106.6 nTPM
Heart muscle	104.1 nTPM
Esophagus	83.8 nTPM
Stomach	67.7 nTPM

Granulocytes	211.2 nTPM
Fallopian tube	266.2 nTPM
Lung	231.4 nTPM
Tongue	135.8 nTPM

Intestinal goblet cells	117.8 nTPM
Colon	135.3 nTPM
Rectum	125.9 nTPM
Small intestine	92.2 nTPM

Bipolar cells	117.7 nTPM
Eye	117.7 nTPM

Cholangiocytes	114.5 nTPM
Liver	114.5 nTPM

Collecting duct cells	103.1 nTPM
Kidney	103.1 nTPM

Cone photoreceptor cells	124.0 nTPM
Eye	124.0 nTPM

Lymphatic endothelial cells	133.1 nTPM
Fallopian tube	189.7 nTPM
Ovary	76.4 nTPM

Macrophages	157.3 nTPM
Endometrium	238.0 nTPM
Adipose tissue	233.0 nTPM
Fallopian tube	223.6 nTPM
Skeletal muscle	207.3 nTPM
Tongue	205.9 nTPM
Salivary gland	172.2 nTPM
Skin	168.3 nTPM
Thymus	148.3 nTPM
Lung	144.9 nTPM
Kidney	141.6 nTPM
Breast	137.0 nTPM
Prostate	136.5 nTPM
Spleen	130.3 nTPM
Pancreas	129.5 nTPM
Stomach	128.6 nTPM
Vascular	128.2 nTPM
Bone marrow	127.7 nTPM
Testis	106.0 nTPM
Esophagus	80.9 nTPM

Paneth cells	78.9 nTPM
Rectum	99.3 nTPM
Small intestine	76.0 nTPM
Colon	61.5 nTPM

Plasma cells	213.6 nTPM
Thymus	385.9 nTPM
Liver	259.4 nTPM
Salivary gland	233.7 nTPM
Spleen	222.8 nTPM
Fallopian tube	221.3 nTPM
Bone marrow	209.9 nTPM
Stomach	97.6 nTPM
Esophagus	78.0 nTPM

Schwann cells	124.8 nTPM
Adipose tissue	244.0 nTPM
Vascular	118.6 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	163.2 nTPM
Salivary gland	193.9 nTPM
Tongue	132.6 nTPM

Smooth muscle cells	147.3 nTPM
Fallopian tube	202.8 nTPM
Endometrium	196.8 nTPM
Ovary	194.1 nTPM
Skeletal muscle	162.0 nTPM
Lung	159.9 nTPM
Adipose tissue	158.1 nTPM
Salivary gland	146.7 nTPM
Vascular	139.7 nTPM
Prostate	139.3 nTPM
Skin	136.6 nTPM
Tongue	131.1 nTPM
Placenta	129.3 nTPM
Thymus	129.0 nTPM
Breast	128.0 nTPM
Liver	112.9 nTPM
Esophagus	90.1 nTPM

Suprabasal keratinocytes	201.0 nTPM
Skin	242.8 nTPM
Tongue	159.2 nTPM

T-cells	152.8 nTPM
Salivary gland	237.7 nTPM
Thymus	236.4 nTPM
Endometrium	225.6 nTPM
Lung	218.7 nTPM
Tongue	198.2 nTPM
Vascular	195.0 nTPM
Adipose tissue	186.6 nTPM
Fallopian tube	173.4 nTPM
Prostate	171.7 nTPM
Skeletal muscle	165.6 nTPM
Liver	144.8 nTPM
Breast	134.6 nTPM
Kidney	121.5 nTPM
PBMC	120.8 nTPM
Skin	116.0 nTPM
Bone marrow	104.4 nTPM
Lymph node	100.2 nTPM
Spleen	91.6 nTPM
Stomach	90.7 nTPM
Colon	88.7 nTPM
Esophagus	87.6 nTPM

Undifferentiated cells	178.2 nTPM
Colon	202.3 nTPM
Small intestine	176.0 nTPM
Rectum	156.3 nTPM

Amygdala excitatory	90.7 nTPM
Hypothalamus	107.7 nTPM
Thalamus	95.7 nTPM
Hippocampus	87.8 nTPM
Amygdala	86.1 nTPM
Cerebral cortex	85.9 nTPM
Basal ganglia	80.8 nTPM

Astrocyte	131.0 nTPM
Amygdala	150.7 nTPM
Cerebral cortex	138.2 nTPM
Hippocampus	136.4 nTPM
Midbrain	132.4 nTPM
Pons	131.8 nTPM
Hypothalamus	131.0 nTPM
Basal ganglia	130.9 nTPM
Thalamus	129.8 nTPM
Spinal cord	128.7 nTPM
Cerebellum	118.7 nTPM
Medulla oblongata	112.6 nTPM

Bergmann glia	108.4 nTPM
Cerebellum	130.7 nTPM
Pons	105.0 nTPM
Medulla oblongata	89.5 nTPM

Central nervous system macrophage	200.4 nTPM
Amygdala	237.5 nTPM
Hippocampus	218.4 nTPM
Cerebellum	213.5 nTPM
Midbrain	207.8 nTPM
Basal ganglia	200.1 nTPM
Cerebral cortex	197.7 nTPM
Hypothalamus	197.6 nTPM
Pons	195.8 nTPM
Thalamus	194.7 nTPM
Spinal cord	176.6 nTPM
Medulla oblongata	164.9 nTPM

Cerebellar inhibitory	101.9 nTPM
Midbrain	108.6 nTPM
Cerebellum	107.8 nTPM
Spinal cord	99.0 nTPM
Medulla oblongata	98.1 nTPM
Pons	96.0 nTPM

Cge interneuron	104.7 nTPM
Hypothalamus	121.3 nTPM
Thalamus	110.1 nTPM
Amygdala	105.7 nTPM
Midbrain	104.8 nTPM
Basal ganglia	99.4 nTPM
Cerebral cortex	98.7 nTPM
Hippocampus	92.7 nTPM

Choroid plexus epithelial cell	172.0 nTPM
Basal ganglia	215.0 nTPM
Hippocampus	188.6 nTPM
Medulla oblongata	158.5 nTPM
Thalamus	126.1 nTPM

Committed oligodendrocyte precursor	119.0 nTPM
Thalamus	157.6 nTPM
Hypothalamus	150.2 nTPM
Midbrain	145.3 nTPM
Amygdala	131.9 nTPM
Hippocampus	125.0 nTPM
Cerebral cortex	121.6 nTPM
Cerebellum	115.7 nTPM
Pons	108.9 nTPM
Basal ganglia	100.7 nTPM
Medulla oblongata	78.8 nTPM
Spinal cord	73.6 nTPM

Deep-layer corticothalamic and 6b	84.8 nTPM
Hypothalamus	97.9 nTPM
Amygdala	89.3 nTPM
Midbrain	85.4 nTPM
Cerebral cortex	83.8 nTPM
Hippocampus	79.0 nTPM
Basal ganglia	73.1 nTPM

Deep-layer intratelencephalic	85.3 nTPM
Amygdala	93.5 nTPM
Hypothalamus	92.9 nTPM
Cerebral cortex	85.2 nTPM
Basal ganglia	78.8 nTPM
Hippocampus	75.9 nTPM