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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.31
Chromosome location (bp)
34236873 - 34246231
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P17096 [Direct mapping] High mobility group protein HMG-I/HMG-Y
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001221[transcription coregulator binding] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0003906[DNA-(apurinic or apyrimidinic site) endonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005694[chromosome] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006268[DNA unwinding involved in DNA replication] GO:0006284[base-excision repair] GO:0006337[nucleosome disassembly] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008285[negative regulation of cell population proliferation] GO:0008301[DNA binding, bending] GO:0019899[enzyme binding] GO:0030374[nuclear receptor coactivator activity] GO:0030527[structural constituent of chromatin] GO:0035985[senescence-associated heterochromatin focus] GO:0042974[nuclear retinoic acid receptor binding] GO:0042975[peroxisome proliferator activated receptor binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046965[nuclear retinoid X receptor binding] GO:0051575[5'-deoxyribose-5-phosphate lyase activity] GO:0060090[molecular adaptor activity] GO:0090402[oncogene-induced cell senescence] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140677[molecular function activator activity]
P17096 [Direct mapping] High mobility group protein HMG-I/HMG-Y
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Q5T6U8 [Target identity:100%; Query identity:100%] High mobility group AT-hook 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001221[transcription coregulator binding] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0003906[DNA-(apurinic or apyrimidinic site) endonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005694[chromosome] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006268[DNA unwinding involved in DNA replication] GO:0006284[base-excision repair] GO:0006337[nucleosome disassembly] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008285[negative regulation of cell population proliferation] GO:0008301[DNA binding, bending] GO:0019899[enzyme binding] GO:0030374[nuclear receptor coactivator activity] GO:0030527[structural constituent of chromatin] GO:0035985[senescence-associated heterochromatin focus] GO:0042974[nuclear retinoic acid receptor binding] GO:0042975[peroxisome proliferator activated receptor binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046965[nuclear retinoid X receptor binding] GO:0051575[5'-deoxyribose-5-phosphate lyase activity] GO:0060090[molecular adaptor activity] GO:0090402[oncogene-induced cell senescence] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140677[molecular function activator activity]
P17096 [Direct mapping] High mobility group protein HMG-I/HMG-Y
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Q5T6U8 [Target identity:100%; Query identity:100%] High mobility group AT-hook 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001221[transcription coregulator binding] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0003906[DNA-(apurinic or apyrimidinic site) endonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005694[chromosome] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006268[DNA unwinding involved in DNA replication] GO:0006284[base-excision repair] GO:0006337[nucleosome disassembly] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008285[negative regulation of cell population proliferation] GO:0008301[DNA binding, bending] GO:0019899[enzyme binding] GO:0030374[nuclear receptor coactivator activity] GO:0030527[structural constituent of chromatin] GO:0035985[senescence-associated heterochromatin focus] GO:0042974[nuclear retinoic acid receptor binding] GO:0042975[peroxisome proliferator activated receptor binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046965[nuclear retinoid X receptor binding] GO:0051575[5'-deoxyribose-5-phosphate lyase activity] GO:0060090[molecular adaptor activity] GO:0090402[oncogene-induced cell senescence] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140677[molecular function activator activity]
P17096 [Direct mapping] High mobility group protein HMG-I/HMG-Y
Show all
Q5T6U8 [Target identity:100%; Query identity:100%] High mobility group AT-hook 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001221[transcription coregulator binding] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0003906[DNA-(apurinic or apyrimidinic site) endonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005694[chromosome] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006268[DNA unwinding involved in DNA replication] GO:0006284[base-excision repair] GO:0006337[nucleosome disassembly] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008285[negative regulation of cell population proliferation] GO:0008301[DNA binding, bending] GO:0019899[enzyme binding] GO:0030374[nuclear receptor coactivator activity] GO:0030527[structural constituent of chromatin] GO:0035985[senescence-associated heterochromatin focus] GO:0042974[nuclear retinoic acid receptor binding] GO:0042975[peroxisome proliferator activated receptor binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046965[nuclear retinoid X receptor binding] GO:0051575[5'-deoxyribose-5-phosphate lyase activity] GO:0060090[molecular adaptor activity] GO:0090402[oncogene-induced cell senescence] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140677[molecular function activator activity]
P17096 [Direct mapping] High mobility group protein HMG-I/HMG-Y
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001221[transcription coregulator binding] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0003906[DNA-(apurinic or apyrimidinic site) endonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005694[chromosome] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006268[DNA unwinding involved in DNA replication] GO:0006284[base-excision repair] GO:0006337[nucleosome disassembly] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008285[negative regulation of cell population proliferation] GO:0008301[DNA binding, bending] GO:0019899[enzyme binding] GO:0030374[nuclear receptor coactivator activity] GO:0030527[structural constituent of chromatin] GO:0035985[senescence-associated heterochromatin focus] GO:0042974[nuclear retinoic acid receptor binding] GO:0042975[peroxisome proliferator activated receptor binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046965[nuclear retinoid X receptor binding] GO:0051575[5'-deoxyribose-5-phosphate lyase activity] GO:0060090[molecular adaptor activity] GO:0090402[oncogene-induced cell senescence] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140677[molecular function activator activity]
A0A669KAX1 [Direct mapping] High mobility group protein HMG-I/HMG-Y
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
