{"Gene":"CCNB1","Gene synonym":["CCNB"],"Ensembl":"ENSG00000134057","Gene description":"Cyclin B1","Uniprot":["P14635"],"Chromosome":"5","Position":"69167135-69178245","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Cyclin"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"52.2","lymphoid tissue":"74.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Cytotrophoblasts":"131.3","Early spermatids":"149.9","Extravillous trophoblasts":"819.0","Oocytes":"341.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"basal ganglia":"3.0","white matter":"8.3"},"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB000115","CAB003804","HPA030741","HPA061448"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 4: Extravillous trophoblasts - Unknown function","Interactions":98,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB000115":null,"CAB003804":"AB_562272","HPA030741":"AB_2673586","HPA061448":"AB_2684522"},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.96e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.21e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.61e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.43e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.11e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.16e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.97e-10"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.69e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.74e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Skin Cuteneous Melanoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.55e-1"}}