Expression of RPS19 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPS19 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 1921.3

Median expressionⁱ : 3324.19

Median follow up timeⁱ : 1.13

P scoreⁱ 0.035

5-year survival highⁱ 3%

5-year survival lowⁱ 9%

TCGA RNA samplesⁱ

Average TPM

3445.7

Number of samples

169

Samples

Sample	Description	TPM
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	9505.9
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	7939.5
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	7190.7
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	7157.6
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	6759.4
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	6757.2
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	6492.7
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	6459.8
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	6392.0
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	6329.3
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	6315.3
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	6211.6
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	6183.5
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	6047.7
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	5962.2
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	5752.6
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	5555.2
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	5444.8
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	5426.4
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	5412.3
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	5323.1
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	5288.2
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	5278.3
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	5241.9
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	5228.9
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	5226.6
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	5183.5
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	5145.3
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	5118.1
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	5078.3
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	4985.0
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	4846.3
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	4807.4
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	4774.2
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	4773.6
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	4758.6
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	4672.2
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	4668.3
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	4654.5
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	4643.8
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	4637.5
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	4524.5
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	4494.6
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	4491.7
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	4435.1
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	4432.5
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	4362.3
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	4348.4
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	4220.6
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	4215.0
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	4202.1
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	4171.2
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	4123.1
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	4081.2
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	4058.9
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	4029.2
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	4000.7
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	3976.7
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	3969.7
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	3955.5
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	3927.3
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	3848.8
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	3847.9
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	3831.5
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	3825.9
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	3802.2
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	3797.5
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	3793.7
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	3780.0
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	3739.5
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	3711.0
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	3700.0
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	3690.4
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	3674.9
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	3651.4
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	3548.7
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	3547.2
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	3524.5
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	3454.7
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	3397.4
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	3377.7
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	3374.3
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	3334.2
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	3334.0
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	3324.2
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	3295.4
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	3290.6
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	3219.5
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	3175.2
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	3162.1
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	3156.1
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	3155.7
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	3142.4
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	3138.1
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	3133.6
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	3000.1
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	2991.5
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	2982.3
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	2930.0
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	2902.2
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	2868.8
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	2849.7
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	2839.9
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	2824.8
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	2776.6
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	2773.2
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	2731.5
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	2720.4
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	2699.4
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	2642.2
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	2611.6
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	2590.2
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	2539.0
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	2505.4
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	2504.6
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	2473.3
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	2423.4
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	2376.3
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	2373.0
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	2349.1
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	2336.4
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	2278.2
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	2270.4
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	2223.1
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	2208.9
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	2134.4
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	2131.3
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	2126.8
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	2087.5
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	2033.3
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	2002.3
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	1953.7
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	1951.4
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	1940.6
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	1933.0
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	1909.6
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	1855.3
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	1808.0
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	1806.1
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	1803.1
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	1786.6
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	1757.6
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	1747.2
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	1647.2
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	1644.9
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	1630.1
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	1593.8
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	1482.4
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	1452.6
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	1399.0
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	1386.1
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	1380.7
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	1370.4
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	1305.1
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	1288.6
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	1278.0
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	1255.4
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	1214.8
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	1159.2
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	1124.3
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	1058.4
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	1055.6
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	1027.1
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	1008.6
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	995.4
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	984.3
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	950.5
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	927.0
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	917.9
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UROTHELIAL CANCER - Protein expressionⁱ

Pending cancer tissue analysis