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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
FDA approved drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q12
Chromosome location (bp)
39173453 - 39197702
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulatory subunit of L-type calcium channels 1,2,3. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane 4. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit 5. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit 6....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Calcium channel, Ion channel, Voltage-gated channel
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Calcium transport, Ion transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0005244[voltage-gated ion channel activity] GO:0005245[voltage-gated calcium channel activity] GO:0005262[calcium channel activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005891[voltage-gated calcium channel complex] GO:0006811[ion transport] GO:0006816[calcium ion transport] GO:0007268[chemical synaptic transmission] GO:0007528[neuromuscular junction development] GO:0008331[high voltage-gated calcium channel activity] GO:0016020[membrane] GO:0034765[regulation of ion transmembrane transport] GO:0042383[sarcolemma] GO:0045202[synapse] GO:0045933[positive regulation of muscle contraction] GO:0070588[calcium ion transmembrane transport] GO:1901385[regulation of voltage-gated calcium channel activity] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:1904646[cellular response to amyloid-beta] GO:1990454[L-type voltage-gated calcium channel complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0005244[voltage-gated ion channel activity] GO:0005245[voltage-gated calcium channel activity] GO:0005262[calcium channel activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005891[voltage-gated calcium channel complex] GO:0006811[ion transport] GO:0006816[calcium ion transport] GO:0007268[chemical synaptic transmission] GO:0007528[neuromuscular junction development] GO:0008331[high voltage-gated calcium channel activity] GO:0016020[membrane] GO:0034765[regulation of ion transmembrane transport] GO:0042383[sarcolemma] GO:0045202[synapse] GO:0045933[positive regulation of muscle contraction] GO:0070588[calcium ion transmembrane transport] GO:1901385[regulation of voltage-gated calcium channel activity] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:1904646[cellular response to amyloid-beta] GO:1990454[L-type voltage-gated calcium channel complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0005244[voltage-gated ion channel activity] GO:0005245[voltage-gated calcium channel activity] GO:0005262[calcium channel activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005891[voltage-gated calcium channel complex] GO:0006811[ion transport] GO:0006816[calcium ion transport] GO:0007268[chemical synaptic transmission] GO:0007528[neuromuscular junction development] GO:0008331[high voltage-gated calcium channel activity] GO:0016020[membrane] GO:0034765[regulation of ion transmembrane transport] GO:0042383[sarcolemma] GO:0045202[synapse] GO:0045933[positive regulation of muscle contraction] GO:0070588[calcium ion transmembrane transport] GO:1901385[regulation of voltage-gated calcium channel activity] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:1904646[cellular response to amyloid-beta] GO:1990454[L-type voltage-gated calcium channel complex]