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Protein Classes

Main classes
Protein classNo of genesCodeNo of genes with
tissue profiles		Source
Kinases 504
Ki
 315 UniProt
CD markers 370
Cd
 233 UniProt
Blood group antigen proteins 29
Ba
 15 UniProt
Transporters 483
Tr
 211 TCDB
Ribosomal proteins 162
Ri
 38 UniProt
Peptidases 522
Pe
 251 UniProt/Merops
GPCRs excl olfactory receptors 395
Gp
 143 UniProt
Transcription factors 1496
Tf
 493 DBD
Enzymes 2567
Ez
 1269 ENZYME
SH2-domain containing proteins 110
Sh
 73 InterPro
SH3-domain containing proteins 217
Sd
 115 InterPro
Voltage-gated ion channels 132
Ic
 54 IUPHAR-DB
 
Project related classes
Protein classNo of genesCodeNo of genes with
tissue profiles		Source
Candidate cancer biomarkers 1068
Cb
 734 Plasma Proteome Institute
Plasma proteins 685
Pp
 424 Plasma Proteome Institute
Candidate cardiovascular disease genes 166
Cc
 118 Plasma Proteome Institute
UniProt - no evidence at protein level 7082
Up
 1373 UniProt
Mutated genes in cancer 385
Cm
 245 Cancer genome project
 
Kinases
Protein classNo of genesCodeNo of genes with
tissue profiles		Source
Kinases 504
Ki
 315 UniProt
AGC Ser/Thr protein kinases 57
Kg
 43 UniProt
CAMK Ser/Thr protein kinases 73
Kc
 43 UniProt
CK1 Ser/Thr protein kinases 12
Kk
 7 UniProt
CMGC Ser/Thr protein kinases 61
Km
 42 UniProt
NEK Ser/Thr protein kinases 11
Kn
 5 UniProt
RGC receptor guanylate cyclase kinases 5
Kr
 1 UniProt
STE Ser/Thr protein kinases 55
Ks
 36 UniProt
TKL Ser/Thr protein kinases 34
Kl
 22 UniProt
Tyr protein kinases 92
Kt
 67 UniProt
Atypical kinases 24
Ka
 12 UniProt
 
Transporters
Protein classNo of genesCodeNo of genes with
tissue profiles		Source
Transporters 483
Tr
 211 TCDB
Transporter channels and pores 166
Tc
 72 TCDB
Electrochemical Potential-driven transporters 136
Te
 51 TCDB
Primary Active Transporters 102
Tp
 53 TCDB
Transport Electron Carriers 9
Tt
 5 TCDB
Accessory Factors Involved in Transport 28
Ta
 13 TCDB
 
Peptidases
Protein classNo of genesCodeNo of genes with
tissue profiles		Source
Peptidases 522
Pe
 251 UniProt/Merops
Aspartic-type peptidases 16
Pa
 10 UniProt/Merops
Cysteine-type peptidases 140
Pc
 71 UniProt/Merops
Metallopeptidases 169
Pm
 80 UniProt/Merops
Serine-type peptidases 170
Ps
 78 UniProt/Merops
Threonine-type peptidases 27
Pt
 12 UniProt/Merops
 
G-protein coupled receptors
Protein classNo of genesCodeNo of genes with
tissue profiles		Source
G-protein coupled receptors 788
Gr
 148 UniProt
Adenosine and adenine nucleotide receptors 17
Ga
 9 UniProt
Chemokines and chemotactic factors receptors 31
Gh
 16 UniProt
Lysolipids receptors 15
Gl
 5 UniProt
Odorant/olfactory and gustatory receptors 393
Go
 5 UniProt
Opsins 10
Gi
 1 UniProt
Serotonin receptors 12
Gs
 7 UniProt
Family 2 (B) receptors 49
Gb
 18 UniProt
Family T2R receptors (taste receptor GPCRs) 19
Gt
 0 UniProt
Family fz/smo receptors 11
Gf
 5 UniProt
GPCRs excl olfactory receptors 395
Gp
 143 UniProt
 
Enzymes
Protein classNo of genesCodeNo of genes with
tissue profiles		Source
Enzymes 2567
Ez
 1269 ENZYME
Oxidoreductases 353
Eo
 153 ENZYME
Transferases 1115
Et
 565 ENZYME
Hydrolases 822
Eh
 414 ENZYME
Lyases 101
Ey
 57 ENZYME
Isomerase 92
Ei
 47 ENZYME
Ligase 126
El
 58 ENZYME
 
Voltage-gated ion channels
Protein classNo of genesCodeNo of genes with
tissue profiles		Source
Voltage-gated ion channels 132
Ic
 54 IUPHAR-DB
Calcium-Activated Potassium Channels 7
Id
 0 IUPHAR-DB
CatSper and Two-Pore Channels 4
Ie
 1 IUPHAR-DB
Cyclic Nucleotide-Regulated Channels 9
If
 2 IUPHAR-DB
Inwardly Rectifying Potassium Channels 15
Ig
 7 IUPHAR-DB
Transient Receptor Potential Channels 24
Ih
 12 IUPHAR-DB
Two-P Potassium Channels 14
Ii
 4 IUPHAR-DB
Voltage-Gated Calcium Channels 10
Ij
 3 IUPHAR-DB
Voltage-Gated Potassium Channels 40
Ik
 21 IUPHAR-DB
Voltage-Gated Sodium Channels 9
Il
 4 IUPHAR-DB
 



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