Human Protein Atlas

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An introduction to Antibody Proteomics

The annotated human genome sequence creates a range of new possibilities for biomedical research and permits a more systematic approach to proteomics (see figure). An attractive strategy involves large scale recombinant expression of proteins and the subsequent generation of specific affinity reagents (antibodies). Such antibodies allow for (i) documentation of expression patterns of a large number of proteins, (ii) specific probes to evaluate the functional role of individual proteins in cellular models, and (iii) purification of significant quantities of proteins and their associated complexes for structural and biochemical analyses. These reagents are therefore valuable tools for many steps in the exploitation of genomic knowledge and these antibodies can subsequently be used in the application of genomics to human diseases and conditions.

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