Immune cell expression cluster

e.g. Metabolic proteins, Localized to mitochondria, Genes tissue enriched in brain (RNA)

Field

Cluster

Pathway

IDⁱ The ID of each cluster.	Main specificityⁱ The annotated specificity of the cluster. This annotation aims to reflect which type of tissues or cell types the genes of the cluster show elevated expression in.	Main functionⁱ The annotated function of the cluster, based on an overrepresentation of genes associated with the annotated function.	# Genesⁱ Number of genes in the cluster.	Annotation reliabilityⁱ The annotation reliability is manually set for all clusters and indicates the level of reliability of the annotated specificity and function.
1	T-cells	Unknown function	202	Low
2	Dendritic cells	Unknown function	342	Low
3	Non-specific	Nuclear processes	471	Medium
4	Neutrophils	Degranulation	86	High
5	Non-specific	Cell proliferation	689	Medium
6	T-cells	T-cell receptor	80	High
7	Non-specific	Innate immune response	237	Low
8	Plasmacytoid DCs	Unknown function	236	Medium
9	T-regs	Cell cycle regulation	166	Low
10	Non-specific	Membrane trafficking	408	Low
11	T-cells	Unknown function	119	Low
12	Non-specific	Mitochondrial translation	566	Medium
13	Non-specific	Mitochondria	458	Medium
14	Non-specific	Unknown function	292	Medium
15	NK-cells	Unknown function	158	Low
16	Non-specific	Cell proliferation	161	Low
17	B-cells	Immunoglobulins	129	High
18	Non-specific	Translation	120	Medium
19	Eosinophils	Unknown function	83	Medium
20	Non-specific	DNA binding	266	Low
21	Neutrophils	Unknown function	492	Low
22	Eosinophils	Transcription	357	Very low
23	B-cells	Immunoglobulins	208	Low
24	Non-specific	Transcription	516	High
25	Non-specific	Unknown function	355	Medium
26	Monocytes	Plasma membrane proteins	79	Low
27	T-cells	Unknown function	41	Low
28	Neutrophils	Unknown function	118	Very low
29	Non-specific	Unknown function	401	Medium
30	Non-specific	DNA binding	263	Low
31	T-cells	T-cell receptor	91	Medium
32	Basophils	Transcription	291	Low
33	Non-specific	ATP binding	757	Medium
34	B-cells	Unknown function	112	Low
35	Neutrophils	Protein binding	504	Low
36	Eosinophils	Protein ubiquitination	179	Very low
37	Monocytes & Neutrophils	Innate immune response	275	Low
38	Monocytes & Neutrophils	Degranulation	501	Medium
39	T-cells	T-cell receptor	56	Low
40	Monocytes	Innate immune response	228	Medium
41	Basophils	Unknown function	293	Low
42	Non-specific	Vesicular transport	519	Very low
43	Non-specific	Transcription & Translation	433	Low
44	Plasmacytoid DCs	Plasma membrane proteins	112	Medium
45	Eosinophils	Unknown function	257	Very low
46	Basophils	Proteolysis	156	Low

The interactive UMAP plot displays the 46 gene clusters resulting from Louvain clustering of gene expression across all immune cell types. General information about the different clusters regarding annotation and number of included genes is shown upon mouse-over, while clicking on a specific cluster in the table will highlight the selected cluster in the plot and display the general information together with a heatmap of the RNA expression across all immune cell type samples for corresponding genes and a Gene Ontology treemap showing the enrichment of GO-terms in the cluster, where applicable.

Granulocytes
T-cells
Dendritic cells
Other
Non-Specific