Single cell type - GAS6 - The Human Protein Atlas

GAS6

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GAS6
Gene descriptionⁱ Full gene name according to HGNC.	Growth arrest specific 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Secretory cells, Granulosa cells, Alveolar cells type 1)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.46
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (plasmacytoid DC)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Secretory cells, Granulosa cells, Alveolar cells type 1)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (plasmacytoid DC)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

GAS6 is part of cluster 53 Fibroblasts - ECM organization with confidenceⁱ 1
305 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KCNK15	Potassium two pore domain channel subfamily K member 15	0.6532	37
IGFBP6	Insulin like growth factor binding protein 6	0.5905	53
NPR1	Natriuretic peptide receptor 1	0.5460	41
CCDC80	Coiled-coil domain containing 80	0.5309	53
TRMT61A	TRNA methyltransferase 61A	0.5297	39
C11orf96	Chromosome 11 open reading frame 96	0.5260	48
ACKR3	Atypical chemokine receptor 3	0.5251	53
RRAS	RAS related	0.5239	32
PTGIS	Prostaglandin I2 synthase	0.5180	53
ZCCHC12	Zinc finger CCHC-type containing 12	0.5124	37
MSLN	Mesothelin	0.5098	37
ITLN1	Intelectin 1	0.5020	16
CCN5	Cellular communication network factor 5	0.5008	53
WNT11	Wnt family member 11	0.4989	53
HES4	Hes family bHLH transcription factor 4	0.4974	48

IMMUNE CELLS

GAS6 is part of cluster 44 Plasmacytoid DCs - Plasma membrane proteins with confidenceⁱ 1
112 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KCNK10	Potassium two pore domain channel subfamily K member 10	1.0000	44
ETV2	ETS variant transcription factor 2	1.0000	44
PTPRS	Protein tyrosine phosphatase receptor type S	1.0000	44
SHD	Src homology 2 domain containing transforming protein D	1.0000	44
CRYM	Crystallin mu	1.0000	44
SLC7A5	Solute carrier family 7 member 5	1.0000	44
PHEX	Phosphate regulating endopeptidase X-linked	1.0000	44
SRPX	Sushi repeat containing protein X-linked	1.0000	44
ASIP	Agouti signaling protein	1.0000	44
MYBL2	MYB proto-oncogene like 2	1.0000	44
CYP46A1	Cytochrome P450 family 46 subfamily A member 1	1.0000	44
DERL3	Derlin 3	1.0000	44
P3H2	Prolyl 3-hydroxylase 2	1.0000	44
EPB41L1	Erythrocyte membrane protein band 4.1 like 1	1.0000	44
MOXD1	Monooxygenase DBH like 1	1.0000	44

Adipocytes	118.3 nTPM
Breast	124.8 nTPM
Adipose tissue	111.7 nTPM

Alveolar cells type 1	295.4 nTPM
Lung	295.4 nTPM

Alveolar cells type 2	13.8 nTPM
Lung	13.8 nTPM

Astrocytes	22.0 nTPM
Brain	22.0 nTPM

B-cells	11.1 nTPM
Lung	41.6 nTPM
Skin	32.2 nTPM
Adipose tissue	20.6 nTPM
Esophagus	17.7 nTPM
Kidney	10.4 nTPM
Thymus	9.5 nTPM
Liver	4.8 nTPM
Salivary gland	3.2 nTPM
Spleen	2.8 nTPM
Stomach	0.8 nTPM
Bone marrow	0.7 nTPM
Lymph node	0.6 nTPM
PBMC	0.0 nTPM

Ciliated cells	74.5 nTPM
Fallopian tube	187.5 nTPM
Lung	52.9 nTPM
Endometrium	35.1 nTPM
Bronchus	22.6 nTPM

Club cells	23.2 nTPM
Lung	36.0 nTPM
Prostate	20.8 nTPM
Bronchus	12.7 nTPM

Dendritic cells	146.7 nTPM
PBMC	161.9 nTPM
Adipose tissue	131.4 nTPM

Endothelial cells	94.7 nTPM
Skeletal muscle	227.2 nTPM
Fallopian tube	173.8 nTPM
Thymus	171.4 nTPM
Prostate	161.6 nTPM
Salivary gland	116.9 nTPM
Heart muscle	105.8 nTPM
Ovary	98.4 nTPM
Breast	91.4 nTPM
Vascular	87.5 nTPM
Esophagus	83.4 nTPM
Lung	79.6 nTPM
Tongue	79.0 nTPM
Liver	71.8 nTPM
Testis	53.4 nTPM
Skin	43.1 nTPM
Endometrium	32.2 nTPM
Pancreas	18.1 nTPM
Placenta	10.2 nTPM

Enteroendocrine cells	56.1 nTPM
Colon	127.5 nTPM
Small intestine	20.6 nTPM
Rectum	20.1 nTPM

Fibroblasts	160.0 nTPM
Adipose tissue	478.8 nTPM
Breast	295.6 nTPM
Thymus	260.4 nTPM
Skeletal muscle	242.3 nTPM
Salivary gland	176.2 nTPM
Fallopian tube	166.5 nTPM
Skin	162.9 nTPM
Vascular	132.2 nTPM
Stomach	128.3 nTPM
Liver	102.0 nTPM
Prostate	99.0 nTPM
Lung	76.8 nTPM
Esophagus	76.1 nTPM
Placenta	75.4 nTPM
Heart muscle	50.0 nTPM
Pancreas	37.8 nTPM

Granulocytes	11.0 nTPM
Fallopian tube	23.6 nTPM
Tongue	4.9 nTPM
Lung	4.5 nTPM

Intestinal goblet cells	62.4 nTPM
Rectum	87.6 nTPM
Colon	53.1 nTPM
Small intestine	46.6 nTPM

Lymphatic endothelial cells	82.6 nTPM
Fallopian tube	127.0 nTPM
Ovary	38.2 nTPM

Macrophages	56.7 nTPM
Skin	230.7 nTPM
Esophagus	101.5 nTPM
Adipose tissue	96.6 nTPM
Vascular	72.5 nTPM
Breast	68.1 nTPM
Skeletal muscle	66.3 nTPM
Thymus	64.5 nTPM
Fallopian tube	62.4 nTPM
Testis	56.4 nTPM
Endometrium	52.9 nTPM
Tongue	47.5 nTPM
Salivary gland	33.4 nTPM
Stomach	28.3 nTPM
Kidney	19.5 nTPM
Bone marrow	18.2 nTPM
Spleen	18.0 nTPM
Prostate	17.6 nTPM
Pancreas	12.3 nTPM
Lung	10.4 nTPM

Basal keratinocytes	62.7 nTPM
Skin	84.2 nTPM
Tongue	41.1 nTPM

Basal prostatic cells	53.6 nTPM
Prostate	53.6 nTPM

Basal respiratory cells	18.5 nTPM
Bronchus	18.5 nTPM

Basal squamous epithelial cells	53.6 nTPM
Esophagus	53.6 nTPM

Paneth cells	73.4 nTPM
Rectum	113.9 nTPM
Colon	61.5 nTPM
Small intestine	44.9 nTPM

Plasma cells	156.2 nTPM
Thymus	245.7 nTPM
Spleen	233.8 nTPM
Bone marrow	184.2 nTPM
Stomach	147.0 nTPM
Liver	125.2 nTPM
Esophagus	114.4 nTPM
Fallopian tube	107.4 nTPM
Salivary gland	92.2 nTPM

Schwann cells	14.1 nTPM
Vascular	25.6 nTPM
Adipose tissue	16.8 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	21.0 nTPM
Salivary gland	24.2 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	156.7 nTPM
Vascular	275.8 nTPM
Lung	258.6 nTPM
Skeletal muscle	255.0 nTPM
Fallopian tube	243.2 nTPM
Adipose tissue	204.9 nTPM
Thymus	192.1 nTPM
Breast	174.7 nTPM
Ovary	167.3 nTPM
Liver	141.4 nTPM
Skin	114.5 nTPM
Esophagus	109.3 nTPM
Tongue	102.4 nTPM
Prostate	79.1 nTPM
Salivary gland	78.5 nTPM
Endometrium	77.7 nTPM
Placenta	33.0 nTPM

Suprabasal keratinocytes	48.7 nTPM
Skin	72.6 nTPM
Tongue	24.8 nTPM

T-cells	4.9 nTPM
Skin	14.0 nTPM
Vascular	11.7 nTPM
Skeletal muscle	11.0 nTPM
Fallopian tube	10.5 nTPM
Endometrium	7.0 nTPM
Prostate	7.0 nTPM
Tongue	5.6 nTPM
Salivary gland	5.0 nTPM
Colon	4.9 nTPM
Lymph node	4.0 nTPM
Breast	3.5 nTPM
Lung	3.4 nTPM
Spleen	2.8 nTPM
Thymus	2.5 nTPM
Esophagus	2.4 nTPM
Adipose tissue	2.0 nTPM
Liver	1.9 nTPM
Kidney	1.8 nTPM
Stomach	1.1 nTPM
PBMC	0.7 nTPM
Bone marrow	0.7 nTPM

Undifferentiated cells	116.9 nTPM
Rectum	140.8 nTPM
Small intestine	111.3 nTPM
Colon	98.7 nTPM

Amygdala excitatory	32.2 nTPM
Hypothalamus	41.7 nTPM
Basal ganglia	36.1 nTPM
Thalamus	32.7 nTPM
Cerebral cortex	29.3 nTPM
Hippocampus	27.3 nTPM
Amygdala	26.1 nTPM

Astrocyte	28.3 nTPM
Cerebral cortex	34.8 nTPM
Pons	33.6 nTPM
Thalamus	31.1 nTPM
Cerebellum	30.7 nTPM
Midbrain	29.0 nTPM
Medulla oblongata	27.5 nTPM
Hippocampus	27.3 nTPM
Basal ganglia	26.0 nTPM
Amygdala	25.8 nTPM
Spinal cord	25.5 nTPM
Hypothalamus	19.4 nTPM

Bergmann glia	16.3 nTPM
Pons	24.5 nTPM
Cerebellum	13.7 nTPM
Medulla oblongata	10.7 nTPM

Central nervous system macrophage	93.8 nTPM
Cerebral cortex	124.4 nTPM
Hippocampus	104.1 nTPM
Amygdala	98.4 nTPM
Cerebellum	98.0 nTPM
Hypothalamus	92.8 nTPM
Thalamus	92.6 nTPM
Pons	88.9 nTPM
Basal ganglia	86.6 nTPM
Midbrain	85.8 nTPM
Medulla oblongata	80.4 nTPM
Spinal cord	79.8 nTPM

Cerebellar inhibitory	68.0 nTPM
Pons	81.4 nTPM
Cerebellum	71.2 nTPM
Midbrain	68.4 nTPM
Medulla oblongata	66.5 nTPM
Spinal cord	52.2 nTPM

Cge interneuron	35.8 nTPM
Hippocampus	44.0 nTPM
Cerebral cortex	40.9 nTPM
Basal ganglia	35.8 nTPM
Amygdala	34.8 nTPM
Midbrain	33.2 nTPM
Hypothalamus	31.9 nTPM
Thalamus	29.7 nTPM

Choroid plexus epithelial cell	62.6 nTPM
Basal ganglia	96.9 nTPM
Medulla oblongata	59.9 nTPM
Hippocampus	52.7 nTPM
Thalamus	41.1 nTPM

Committed oligodendrocyte precursor	27.0 nTPM
Medulla oblongata	38.7 nTPM
Thalamus	38.3 nTPM
Basal ganglia	30.1 nTPM
Spinal cord	29.4 nTPM
Pons	29.2 nTPM
Cerebellum	27.0 nTPM
Cerebral cortex	24.7 nTPM
Midbrain	22.7 nTPM
Hippocampus	22.5 nTPM
Amygdala	17.5 nTPM
Hypothalamus	17.1 nTPM

Deep-layer corticothalamic and 6b	41.9 nTPM
Midbrain	46.6 nTPM
Cerebral cortex	45.7 nTPM
Hippocampus	44.9 nTPM
Basal ganglia	38.7 nTPM
Hypothalamus	38.2 nTPM
Amygdala	37.4 nTPM

Deep-layer intratelencephalic	29.6 nTPM
Hippocampus	32.7 nTPM
Cerebral cortex	32.0 nTPM
Hypothalamus	31.8 nTPM
Amygdala	27.3 nTPM
Basal ganglia	24.3 nTPM

Deep-layer near-projecting	50.5 nTPM
Hippocampus	68.6 nTPM
Cerebral cortex	56.3 nTPM
Amygdala	50.3 nTPM
Hypothalamus	39.6 nTPM
Basal ganglia	37.6 nTPM

Eccentric medium spiny neuron	39.0 nTPM
Hippocampus	44.4 nTPM
Hypothalamus	43.0 nTPM
Cerebral cortex	39.4 nTPM
Thalamus	37.9 nTPM
Amygdala	35.7 nTPM
Basal ganglia	33.5 nTPM