Single cell type - MERTK - The Human Protein Atlas

MERTK

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MERTK
Gene descriptionⁱ Full gene name according to HGNC.	MER proto-oncogene, tyrosine kinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Astrocytes, Microglial cells, Kupffer cells, Macrophages)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.72
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Central nervous system macrophage, Bergmann glia)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (intermediate monocyte, non-classical monocyte)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Astrocytes, Microglial cells, Kupffer cells, Macrophages)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Central nervous system macrophage, Bergmann glia)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (intermediate monocyte, non-classical monocyte)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MERTK is part of cluster 58 Macrophages - Innate immune response with confidenceⁱ 1
420 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD163	CD163 molecule	0.8224	58
LILRB5	Leukocyte immunoglobulin like receptor B5	0.7991	58
FOLR2	Folate receptor beta	0.7850	58
ADAP2	ArfGAP with dual PH domains 2	0.7813	58
GPR34	G protein-coupled receptor 34	0.7813	58
LYVE1	Lymphatic vessel endothelial hyaluronan receptor 1	0.7757	58
ADORA3	Adenosine A3 receptor	0.7721	58
GSDMA	Gasdermin A	0.7654	58
CSF1R	Colony stimulating factor 1 receptor	0.7635	58
SIGLEC1	Sialic acid binding Ig like lectin 1	0.7575	58
CD209	CD209 molecule	0.7550	58
RNASE1	Ribonuclease A family member 1, pancreatic	0.7370	58
MS4A4A	Membrane spanning 4-domains A4A	0.7253	58
HMOX1	Heme oxygenase 1	0.7233	58
C1QC	Complement C1q C chain	0.7224	58

IMMUNE CELLS

MERTK is part of cluster 40 Monocytes - Innate immune response with confidenceⁱ 0.99
228 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
APOBEC3A	Apolipoprotein B mRNA editing enzyme catalytic subunit 3A	1.0000	40
KCNMA1	Potassium calcium-activated channel subfamily M alpha 1	1.0000	40
SLC5A10	Solute carrier family 5 member 10	1.0000	40
UTRN	Utrophin	1.0000	40
CLEC4F	C-type lectin domain family 4 member F	1.0000	40
CDH13	Cadherin 13	1.0000	40
CTSL	Cathepsin L	1.0000	40
SFTPD	Surfactant protein D	1.0000	40
CDKN1C	Cyclin dependent kinase inhibitor 1C	1.0000	40
KNSTRN	Kinetochore localized astrin (SPAG5) binding protein	1.0000	40
MSR1	Macrophage scavenger receptor 1	1.0000	40
AVPR2	Arginine vasopressin receptor 2	1.0000	40
RRAS	RAS related	1.0000	40
NR4A1	Nuclear receptor subfamily 4 group A member 1	1.0000	40
SASH1	SAM and SH3 domain containing 1	1.0000	40

Adipocytes	7.9 nTPM
Adipose tissue	8.9 nTPM
Breast	6.9 nTPM

Alveolar cells type 1	1.4 nTPM
Lung	1.4 nTPM

Alveolar cells type 2	7.8 nTPM
Lung	7.8 nTPM

B-cells	2.9 nTPM
Adipose tissue	11.9 nTPM
Esophagus	11.8 nTPM
Lung	5.4 nTPM
Liver	4.8 nTPM
Skin	1.7 nTPM
Thymus	1.1 nTPM
Salivary gland	0.5 nTPM
Stomach	0.4 nTPM
Lymph node	0.2 nTPM
Spleen	0.1 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Basal keratinocytes	1.2 nTPM
Tongue	1.4 nTPM
Skin	1.0 nTPM

Ciliated cells	3.9 nTPM
Endometrium	7.7 nTPM
Lung	3.5 nTPM
Fallopian tube	2.7 nTPM
Bronchus	1.7 nTPM

Club cells	2.8 nTPM
Prostate	5.2 nTPM
Lung	3.0 nTPM
Bronchus	0.2 nTPM

Endothelial cells	9.9 nTPM
Liver	25.2 nTPM
Placenta	23.8 nTPM
Fallopian tube	14.5 nTPM
Skin	12.7 nTPM
Esophagus	12.5 nTPM
Salivary gland	10.5 nTPM
Thymus	8.7 nTPM
Ovary	8.6 nTPM
Vascular	8.4 nTPM
Prostate	7.9 nTPM
Skeletal muscle	7.8 nTPM
Endometrium	6.9 nTPM
Lung	6.6 nTPM
Tongue	6.3 nTPM
Heart muscle	5.3 nTPM
Pancreas	5.2 nTPM
Testis	4.6 nTPM
Breast	2.6 nTPM

Enteroendocrine cells	0.6 nTPM
Colon	1.8 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	6.5 nTPM
Liver	45.1 nTPM
Prostate	15.8 nTPM
Skin	6.6 nTPM
Salivary gland	4.4 nTPM
Stomach	4.3 nTPM
Breast	4.3 nTPM
Placenta	4.2 nTPM
Vascular	4.0 nTPM
Lung	3.5 nTPM
Fallopian tube	3.2 nTPM
Thymus	3.0 nTPM
Heart muscle	2.3 nTPM
Esophagus	1.5 nTPM
Skeletal muscle	1.0 nTPM
Adipose tissue	0.6 nTPM
Pancreas	0.1 nTPM

Granulocytes	3.4 nTPM
Tongue	4.9 nTPM
Lung	4.0 nTPM
Fallopian tube	1.5 nTPM

Intestinal goblet cells	2.6 nTPM
Rectum	4.4 nTPM
Colon	2.0 nTPM
Small intestine	1.3 nTPM

Lymphatic endothelial cells	10.1 nTPM
Ovary	10.9 nTPM
Fallopian tube	9.3 nTPM

Macrophages	62.0 nTPM
Vascular	178.0 nTPM
Thymus	151.6 nTPM
Prostate	116.5 nTPM
Salivary gland	113.8 nTPM
Spleen	88.2 nTPM
Bone marrow	79.1 nTPM
Adipose tissue	75.7 nTPM
Esophagus	62.9 nTPM
Breast	51.0 nTPM
Stomach	48.9 nTPM
Fallopian tube	43.6 nTPM
Testis	35.3 nTPM
Tongue	32.1 nTPM
Skeletal muscle	27.6 nTPM
Kidney	18.6 nTPM
Lung	17.3 nTPM
Pancreas	14.4 nTPM
Endometrium	12.9 nTPM
Skin	10.0 nTPM

Paneth cells	1.7 nTPM
Small intestine	3.5 nTPM
Rectum	1.7 nTPM
Colon	0.0 nTPM

Astrocytes	154.2 nTPM
Brain	154.2 nTPM

Plasma cells	26.7 nTPM
Fallopian tube	94.6 nTPM
Salivary gland	80.6 nTPM
Esophagus	15.6 nTPM
Liver	8.0 nTPM
Stomach	6.7 nTPM
Bone marrow	4.5 nTPM
Thymus	3.1 nTPM
Spleen	0.5 nTPM

Schwann cells	2.2 nTPM
Vascular	6.3 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	2.2 nTPM
Salivary gland	4.4 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	10.8 nTPM
Thymus	22.4 nTPM
Prostate	17.6 nTPM
Skeletal muscle	16.8 nTPM
Esophagus	14.4 nTPM
Vascular	12.8 nTPM
Skin	12.1 nTPM
Lung	11.8 nTPM
Breast	10.7 nTPM
Ovary	10.7 nTPM
Liver	9.3 nTPM
Fallopian tube	9.2 nTPM
Salivary gland	8.8 nTPM
Adipose tissue	7.8 nTPM
Endometrium	3.6 nTPM
Tongue	3.6 nTPM
Placenta	1.9 nTPM

T-cells	1.0 nTPM
Vascular	3.2 nTPM
Prostate	3.1 nTPM
Endometrium	1.7 nTPM
Liver	1.6 nTPM
Skeletal muscle	1.5 nTPM
Thymus	1.5 nTPM
Salivary gland	1.3 nTPM
Skin	1.1 nTPM
Lymph node	0.9 nTPM
Fallopian tube	0.9 nTPM
Lung	0.8 nTPM
Tongue	0.8 nTPM
Stomach	0.6 nTPM
Breast	0.6 nTPM
Adipose tissue	0.3 nTPM
Spleen	0.2 nTPM
PBMC	0.1 nTPM
Bone marrow	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	1.7 nTPM
Rectum	3.0 nTPM
Small intestine	1.3 nTPM
Colon	0.7 nTPM

Amygdala excitatory	2.5 nTPM
Amygdala	3.4 nTPM
Thalamus	2.7 nTPM
Basal ganglia	2.6 nTPM
Hypothalamus	2.1 nTPM
Cerebral cortex	2.0 nTPM
Hippocampus	2.0 nTPM

Astrocyte	179.3 nTPM
Cerebral cortex	400.2 nTPM
Amygdala	342.8 nTPM
Hippocampus	271.9 nTPM
Basal ganglia	182.6 nTPM
Thalamus	170.7 nTPM
Hypothalamus	154.2 nTPM
Midbrain	142.2 nTPM
Cerebellum	104.4 nTPM
Pons	97.7 nTPM
Medulla oblongata	63.9 nTPM
Spinal cord	42.2 nTPM

Bergmann glia	214.6 nTPM
Cerebellum	222.0 nTPM
Pons	221.5 nTPM
Medulla oblongata	200.3 nTPM

Central nervous system macrophage	478.3 nTPM
Amygdala	987.2 nTPM
Hippocampus	753.4 nTPM
Cerebral cortex	736.5 nTPM
Thalamus	523.9 nTPM
Hypothalamus	410.5 nTPM
Midbrain	391.4 nTPM
Basal ganglia	382.6 nTPM
Pons	294.5 nTPM
Cerebellum	285.5 nTPM
Spinal cord	261.7 nTPM
Medulla oblongata	234.4 nTPM

Cerebellar inhibitory	15.3 nTPM
Medulla oblongata	18.4 nTPM
Midbrain	15.2 nTPM
Pons	14.5 nTPM
Cerebellum	14.4 nTPM
Spinal cord	13.7 nTPM

Cge interneuron	10.2 nTPM
Hypothalamus	13.2 nTPM
Basal ganglia	12.4 nTPM
Amygdala	11.6 nTPM
Hippocampus	9.8 nTPM
Cerebral cortex	9.1 nTPM
Thalamus	9.0 nTPM
Midbrain	6.5 nTPM

Choroid plexus epithelial cell	170.0 nTPM
Basal ganglia	240.0 nTPM
Medulla oblongata	153.3 nTPM
Hippocampus	152.5 nTPM
Thalamus	134.3 nTPM

Committed oligodendrocyte precursor	12.6 nTPM
Basal ganglia	35.6 nTPM
Medulla oblongata	19.4 nTPM
Cerebral cortex	17.1 nTPM
Hippocampus	15.5 nTPM
Amygdala	12.4 nTPM
Pons	8.0 nTPM
Cerebellum	7.9 nTPM
Hypothalamus	7.5 nTPM
Spinal cord	7.4 nTPM
Thalamus	4.1 nTPM
Midbrain	3.4 nTPM

Deep-layer corticothalamic and 6b	3.0 nTPM
Hypothalamus	5.9 nTPM
Basal ganglia	3.9 nTPM
Amygdala	2.9 nTPM
Cerebral cortex	2.8 nTPM
Hippocampus	1.6 nTPM
Midbrain	1.1 nTPM

Deep-layer intratelencephalic	5.5 nTPM
Hypothalamus	10.0 nTPM
Cerebral cortex	6.9 nTPM
Basal ganglia	5.1 nTPM
Hippocampus	3.2 nTPM
Amygdala	2.6 nTPM

Deep-layer near-projecting	1.3 nTPM
Hypothalamus	3.9 nTPM
Cerebral cortex	1.1 nTPM
Basal ganglia	1.0 nTPM
Amygdala	0.7 nTPM
Hippocampus	0.0 nTPM

Eccentric medium spiny neuron	18.4 nTPM
Thalamus	34.1 nTPM
Basal ganglia	30.4 nTPM
Hippocampus	27.4 nTPM
Cerebral cortex	7.4 nTPM
Amygdala	5.5 nTPM
Hypothalamus	5.4 nTPM

Endothelial cell	165.9 nTPM
Hypothalamus	333.7 nTPM
Amygdala	173.3 nTPM
Cerebellum	170.4 nTPM
Medulla oblongata	167.2 nTPM
Cerebral cortex	154.7 nTPM
Basal ganglia	151.0 nTPM
Midbrain	149.3 nTPM
Thalamus	138.4 nTPM
Spinal cord	132.9 nTPM
Pons	129.2 nTPM
Hippocampus	125.3 nTPM

Ependymal cell	31.5 nTPM
Amygdala	49.5 nTPM
Hypothalamus	43.7 nTPM
Basal ganglia	41.3 nTPM
Thalamus	35.6 nTPM
Midbrain	33.6 nTPM
Hippocampus	31.7 nTPM
Pons	22.0 nTPM
Medulla oblongata	18.0 nTPM
Spinal cord	7.7 nTPM